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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Selective gene expression profiling contributes to a better understanding of the molecular pathways underlying the histological changes observed after RHMVL

Fig. 1

Diagram of different vasoactive molecular pathways involved in the regulation of hepatic hemodynamics. List of interactions between pathways: blue arrows—enhancing effect, red arrows—inhibitory effect; dark blue tiles: interrelated drug classes; yellow text—drug classes with substance investigated in previous studies; orange box—investigated genes, By courtesy of Springer Nature: Modified figure of previously published figure in Arlt et al. (2017) [29]. List of abbreviations: Adora, Adenosine receptor; Ca2+- Calcium; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; DAG Diacylglycerol; Edn1-Endothelin 1; Ednra, Endothelin receptor type A; nEdra, Endothelin receptor type B 1/2; GTP, Guanosine triphosphate; GucY1a2- Guanylate cyclase soluble subunit alpha-2; IP3, Inositol 1,4,5-trisphosphate; K+ -Potassium; NO, Nitric oxide; NOS, Nitric oxide synthases; PA- Phosphatidic acid; PGH2, Prostaglandin H2; PGI2, Prostacyclin; Ptgis -Prostacyclin synthase; PIP2, Phosphatidylinositol 4,5-bisphosphate; PKC- Protein kinase C; PLC -Phospholipase C; PLD, Phospholipase D; Ptgs 1/2 -Cyclooxygenase-1/2; TXA2- thromboxane A2; Tbxa2r -Thromboxane A2 Receptor; Tbxas1- Thromboxane synthase

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