Fig. 3

Clustering by gene expression: A Principle component analysis (PCA). Principle component analysis (PC1 versus PC2) based on transcriptome data of 37 genes in 12 sample groups (NZ- normal Zone (green); OZ—obstruction Zone (red); BZ- border Zone (blue)) and the observation time (0 h, 24 h, 48 h, and 168 h post-OP). The sample groups could be grouped into three clusters (C1-red, C2-blue, and C3-yellow). B Venn diagram. Venn diagram grouped 11 DEGs (adjusted p-value < 0,05 and fold change ≤ 0,33 or ≥ 3) within the three tissue zones (NZ, BZ, and OZ). Numbers represent the numbers of genes detected in tissue zones or their various overlapping subsets