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Table 3 Examples of studies on the regulation of iNOS in the liver

From: Selective gene expression profiling contributes to a better understanding of the molecular pathways underlying the histological changes observed after RHMVL

Drug

Treatment

Species

Result

References

Aminoguanidine

Phx

rat

Decreased iNOS protein level

[75]

 

LPS

rat

Attenuated LPS-induced hepatotoxicity

[76]

ONO-1714

Phx

pig

Reduced liver damage

[77]

 

I/R

pig

Reduced liver ischemia–reperfusion damage

[78]

 

I/R

pig

Reduced liver damage & stabilized hemodynamics

[79]

Sivelestat

I/R

rat

Prevented hepatic I/R injury

[80]

1400 W

transplantation

rat

Effective therapy for primary nonfunction of fatty liver grafts

[81]

 

I/R

rat

Decreased NO metabolites level in serum

[82]

 

ICC

tissue / cell

Suppressed cell proliferation, invasion, and migration in ICC

[83]

microRNA149

LPS

mice

Reduced inflammation in liver

[84]

asRNA

–

HC rat

Reduced iNOS mRNA levels

[85]

  1. asRNAs Antisense RNA; HC Hepatocytes cells, I/R Ischemia–reperfusion, Phx Partial hepatectomy, ICC Intrahepatic cholangiocarcinoma