Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population

Table 3 Genetic model analyses of the association between CYP4B1 polymorphisms and the risk of gastric cancer (adjusted for gender, age, smoking and drinking)

SNP-ID	Model	Genotype	Case		Control		Adjusted by gender, age, smoking and drinking
SNP-ID	Model	Genotype	n	%	n	%	OR (95% CI)	p
rs2297810	allele	A	364	25.82	359	25.39	1.02 (0.86–1.21)	0.795
		G	1046	74.18	1055	74.61	1.00
	genotype	AA	43	6.10	50	7.07	0.89 (0.58–1.37)	0.595
		AG	278	39.43	259	36.63	1.11 (0.89–1.39)	0.340
		GG	384	54.47	398	56.30	1.00
	dominant	AA-AG	321	45.53	309	43.71	1.08 (0.87–1.33)	0.490
		GG	384	54.47	398	56.29	1.00
	recessive	AA	43	6.10	50	7.07	0.85 (0.56–1.30)	0.456
		AG-GG	662	93.90	657	92.93	1.00
	additive	---	---	---	---	---	1.02 (0.86–1.21)	0.798
rs4646491	allele	T	388	27.60	359	25.39	1.12 (0.95–1.32)	0.184
		C	1018	72.40	1055	74.61	1.00
	genotype	TT	34	4.84	49	6.93	0.79 (0.50–1.25)	0.309
		TC	320	45.52	261	36.92	1.40 (1.13–1.74)	0.002
		CC	349	49.64	397	56.15	1.00
	dominant	TT-TC	354	50.36	310	43.85	1.30 (1.06–1.61)	0.014
		CC	349	49.64	397	56.15	1.00
	recessive	TT	34	4.84	49	6.93	0.68 (0.43–1.07)	0.094
		TC-CC	669	95.16	658	93.07	1.00
	additive	---	---	---	---	---	1.13 (0.95–1.34)	0.167
rs2297809	allele	T	359	25.42	356	25.25	1.01 (0.09–0.85)	0.914
		C	1053	74.58	1054	74.75	1.00
	genotype	TT	38	5.38	49	6.95	0.80 (0.51–1.25)	0.324
		TC	283	40.08	258	36.60	1.14 (0.91–1.42)	0.253
		CC	385	54.54	398	56.45	1.00
	dominant	TT-TC	321	45.47	307	43.55	1.08 (0.88–1.34)	0.460
		CC	385	54.53	398	56.45	1.00
	recessive	TT	38	5.38	49	6.95	0.76 (0.49–1.18)	0.215
		TC-CC	668	94.62	656	93.05	1.00
	additive	---	---	---	---	---	1.01 (0.85–1.20)	0.911

SNP: single nucleotide polymorphism; n: number; OR: Odds ratio; 95% CI: 95% Confidence interval.
p < 0.05 indicates statistical significance.

ISSN: 1755-8794