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Table 4 Stratified analyses between SNPs on CYP4B1 and gastric cancer risk by gender, smoking and alcohol under different genotypic models

From: Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population

SNP-ID

Model

Genotype

Gender stratification

Smoking stratification

Drinking stratification

Males

Females

Yes

No

Yes

No

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

rs2297810

allele

A

1.03 (0.85–1.25)

0.748

0.99 (0.70–1.41)

0.965

1.03 (0.81–1.31)

0.830

1.02 (0.80–1.29)

0.879

1.04 (0.81–1.32)

0.783

1.01 (0.80–1.28)

0.918

  

G

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

genotype

AA

0.91 (0.55–1.51)

0.714

0.95 (0.40–2.25)

0.909

0.89 (0.48–1.66)

0.722

0.90 (0.49–1.64)

0.726

0.94 (0.50–1.78)

0.860

0.90 (0.49–1.63)

0.717

  

AG

1.11 (0.87–1.43)

0.405

1.17 (0.73–1.86)

0.514

1.12 (0.82–1.53)

0.481

1.15 (0.84–1.57)

0.387

1.14 (0.83–1.57)

0.403

1.13 (0.83–1.54)

0.443

  

GG

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

dominant

AA-AG

1.08 (0.85–1.38)

0.522

1.13 (0.73–1.75)

0.592

1.08 (0.80–1.46)

0.600

1.11 (0.82–1.49)

0.509

1.11 (0.82–1.51)

0.486

1.09 (0.81–1.47)

0.569

  

GG

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

recessive

AA

0.87 (0.53–1.43)

0.583

0.90 (0.39–2.07)

0.798

0.85 (0.46–1.57)

0.610

0.85 (0.47–1.53)

0.587

0.89 (0.48–1.66)

0.723

0.85 (0.47–1.53)

0.593

  

AG-GG

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

additive

---

1.03 (0.85–1.25)

0.763

1.06 (0.75–1.49)

0.753

1.03 (0.81–1.31)

0.825

1.04 (0.82–1.32)

0.757

1.05 (0.83–1.35)

0.672

1.03 (0.81–1.30)

0.811

rs4646491

allele

T

1.13 (0.93–1.36)

0.222

1.10 (0.78–1.56)

0.594

1.09 (0.86–1.38)

0.486

1.15 (0.91–1.46)

0.238

1.09 (0.86–1.38)

0.488

1.15 (0.91–1.46)

0.233

  

C

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

genotype

TT

0.86 (0.50–1.46)

0.567

0.69 (0.26–1.82)

0.454

0.77 (0.40–1.48)

0.432

0.82 (0.43–1.58)

0.551

0.81 (0.42–1.57)

0.531

0.82 (0.43–1.57)

0.547

  

TC

1.36 (1.06–1.75)

0.015

1.57 (0.99–2.48)

0.055

1.33 (0.98–1.82)

0.069

1.52 (1.11–2.07)

0.009

1.36 (0.99–1.86)

0.054

1.50 (1.10–2.04)

0.010

  

CC

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

dominant

TT-TC

1.29 (1.01–1.64)

0.040

1.40 (0.90–2.18)

0.132

1.24 (0.92–1.68)

0.151

1.40 (1.04–1.89)

0.027

1.28 (0.94–1.73)

0.115

1.39 (1.03–1.87)

0.030

  

CC

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

recessive

TT

0.75 (0.45–1.26)

0.272

0.58 (0.22–1.49)

0.255

0.68 (0.36–1.29)

0.237

0.69 (0.36–1.30)

0.247

0.71 (0.37–1.36)

0.301

0.69 (0.36–1.29)

0.244

  

TC-CC

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

additive

---

1.14 (0.93–1.39)

0.202

1.15 (0.81–1.65)

0.436

1.10 (0.86–1.40)

0.468

1.19 (0.93–1.52)

0.172

1.12 (0.87–1.44)

0.367

1.18 (0.92–1.50)

0.185

rs2297809

allele

T

1.01 (0.83–1.22)

0.942

1.02 (0.71–1.45)

0.928

0.97 (0.76–1.23)

0.806

1.05 (0.83–1.33)

0.691

1.01 (0.79–1.29)

0.926

1.01 (0.80–1.28)

0.945

  

C

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

genotype

TT

0.86 (0.51–1.44)

0.559

0.73 (0.29–1.85)

0.505

0.77 (0.41–1.46)

0.430

0.83 (0.44–1.56)

0.563

0.88 (0.46–1.66)

0.685

0.77 (0.41–1.45)

0.420

  

TC

1.09 (0.85–1.40)

0.508

1.41 (0.88–2.25)

0.151

1.07 (0.78–1.46)

0.692

1.26 (0.92–1.72)

0.152

1.14 (0.83–1.57)

0.417

1.19 (0.87–1.61)

0.282

  

CC

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

dominant

TT-TC

1.05 (0.83–1.34)

0.668

1.28 (0.82–1.99)

0.283

1.02 (0.76–1.37)

0.899

1.19 (0.88–1.60)

0.265

1.10 (0.81–1.49)

0.544

1.12 (0.83–1.50)

0.461

  

CC

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

recessive

TT

0.83 (0.50–1.37)

0.465

0.64 (0.26–1.59)

0.335

0.75 (0.40–1.41)

0.376

0.76 (0.41–1.41)

0.378

0.83 (0.45–1.55)

0.563

0.72 (0.38–1.34)

0.297

  

TC-CC

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 

1.00

 
 

additive

---

1.01 (0.83–1.23)

0.948

1.09 (0.76–1.55)

0.636

0.97 (0.76–1.24)

0.806

1.07 (0.84–1.37)

0.579

1.03 (0.81–1.32)

0.791

1.02 (0.80–1.30)

0.850

  1. SNP: single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% Confidence interval.
  2. p < 0.05 indicates statistical significance.