SNP-ID | Model | Genotype | Gender stratification | Smoking stratification | Drinking stratification | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Males | Females | Yes | No | Yes | No | |||||||||
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
rs2297810 | allele | A | 1.03 (0.85–1.25) | 0.748 | 0.99 (0.70–1.41) | 0.965 | 1.03 (0.81–1.31) | 0.830 | 1.02 (0.80–1.29) | 0.879 | 1.04 (0.81–1.32) | 0.783 | 1.01 (0.80–1.28) | 0.918 |
G | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
genotype | AA | 0.91 (0.55–1.51) | 0.714 | 0.95 (0.40–2.25) | 0.909 | 0.89 (0.48–1.66) | 0.722 | 0.90 (0.49–1.64) | 0.726 | 0.94 (0.50–1.78) | 0.860 | 0.90 (0.49–1.63) | 0.717 | |
AG | 1.11 (0.87–1.43) | 0.405 | 1.17 (0.73–1.86) | 0.514 | 1.12 (0.82–1.53) | 0.481 | 1.15 (0.84–1.57) | 0.387 | 1.14 (0.83–1.57) | 0.403 | 1.13 (0.83–1.54) | 0.443 | ||
GG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
dominant | AA-AG | 1.08 (0.85–1.38) | 0.522 | 1.13 (0.73–1.75) | 0.592 | 1.08 (0.80–1.46) | 0.600 | 1.11 (0.82–1.49) | 0.509 | 1.11 (0.82–1.51) | 0.486 | 1.09 (0.81–1.47) | 0.569 | |
GG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
recessive | AA | 0.87 (0.53–1.43) | 0.583 | 0.90 (0.39–2.07) | 0.798 | 0.85 (0.46–1.57) | 0.610 | 0.85 (0.47–1.53) | 0.587 | 0.89 (0.48–1.66) | 0.723 | 0.85 (0.47–1.53) | 0.593 | |
AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
additive | --- | 1.03 (0.85–1.25) | 0.763 | 1.06 (0.75–1.49) | 0.753 | 1.03 (0.81–1.31) | 0.825 | 1.04 (0.82–1.32) | 0.757 | 1.05 (0.83–1.35) | 0.672 | 1.03 (0.81–1.30) | 0.811 | |
rs4646491 | allele | T | 1.13 (0.93–1.36) | 0.222 | 1.10 (0.78–1.56) | 0.594 | 1.09 (0.86–1.38) | 0.486 | 1.15 (0.91–1.46) | 0.238 | 1.09 (0.86–1.38) | 0.488 | 1.15 (0.91–1.46) | 0.233 |
C | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
genotype | TT | 0.86 (0.50–1.46) | 0.567 | 0.69 (0.26–1.82) | 0.454 | 0.77 (0.40–1.48) | 0.432 | 0.82 (0.43–1.58) | 0.551 | 0.81 (0.42–1.57) | 0.531 | 0.82 (0.43–1.57) | 0.547 | |
TC | 1.36 (1.06–1.75) | 0.015 | 1.57 (0.99–2.48) | 0.055 | 1.33 (0.98–1.82) | 0.069 | 1.52 (1.11–2.07) | 0.009 | 1.36 (0.99–1.86) | 0.054 | 1.50 (1.10–2.04) | 0.010 | ||
CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
dominant | TT-TC | 1.29 (1.01–1.64) | 0.040 | 1.40 (0.90–2.18) | 0.132 | 1.24 (0.92–1.68) | 0.151 | 1.40 (1.04–1.89) | 0.027 | 1.28 (0.94–1.73) | 0.115 | 1.39 (1.03–1.87) | 0.030 | |
CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
recessive | TT | 0.75 (0.45–1.26) | 0.272 | 0.58 (0.22–1.49) | 0.255 | 0.68 (0.36–1.29) | 0.237 | 0.69 (0.36–1.30) | 0.247 | 0.71 (0.37–1.36) | 0.301 | 0.69 (0.36–1.29) | 0.244 | |
TC-CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
additive | --- | 1.14 (0.93–1.39) | 0.202 | 1.15 (0.81–1.65) | 0.436 | 1.10 (0.86–1.40) | 0.468 | 1.19 (0.93–1.52) | 0.172 | 1.12 (0.87–1.44) | 0.367 | 1.18 (0.92–1.50) | 0.185 | |
rs2297809 | allele | T | 1.01 (0.83–1.22) | 0.942 | 1.02 (0.71–1.45) | 0.928 | 0.97 (0.76–1.23) | 0.806 | 1.05 (0.83–1.33) | 0.691 | 1.01 (0.79–1.29) | 0.926 | 1.01 (0.80–1.28) | 0.945 |
C | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
genotype | TT | 0.86 (0.51–1.44) | 0.559 | 0.73 (0.29–1.85) | 0.505 | 0.77 (0.41–1.46) | 0.430 | 0.83 (0.44–1.56) | 0.563 | 0.88 (0.46–1.66) | 0.685 | 0.77 (0.41–1.45) | 0.420 | |
TC | 1.09 (0.85–1.40) | 0.508 | 1.41 (0.88–2.25) | 0.151 | 1.07 (0.78–1.46) | 0.692 | 1.26 (0.92–1.72) | 0.152 | 1.14 (0.83–1.57) | 0.417 | 1.19 (0.87–1.61) | 0.282 | ||
CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
dominant | TT-TC | 1.05 (0.83–1.34) | 0.668 | 1.28 (0.82–1.99) | 0.283 | 1.02 (0.76–1.37) | 0.899 | 1.19 (0.88–1.60) | 0.265 | 1.10 (0.81–1.49) | 0.544 | 1.12 (0.83–1.50) | 0.461 | |
CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
recessive | TT | 0.83 (0.50–1.37) | 0.465 | 0.64 (0.26–1.59) | 0.335 | 0.75 (0.40–1.41) | 0.376 | 0.76 (0.41–1.41) | 0.378 | 0.83 (0.45–1.55) | 0.563 | 0.72 (0.38–1.34) | 0.297 | |
TC-CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
additive | --- | 1.01 (0.83–1.23) | 0.948 | 1.09 (0.76–1.55) | 0.636 | 0.97 (0.76–1.24) | 0.806 | 1.07 (0.84–1.37) | 0.579 | 1.03 (0.81–1.32) | 0.791 | 1.02 (0.80–1.30) | 0.850 |