Table 1 Top 10 enriched GO terms assigned to the text mining genes

Cytokine-mediated signaling pathway

2.02245E−57

CDKN1A, CD4, GRAP2, CASP3, TNFSF11, VIM, VEGFA, VCAM1, TP53, TNFRSF1B, TNF, TIMP1, TGFB1, SHC1, CCL5, CCL2, SAA1, BCL2, RELA, PTGS2, PRTN3, POMC, PF4, MUC1, MMP9, MMP3, MMP2, MMP1, KIT, JAK2, ITGAM, FASLG, IL18, IL17A, IL10, IL8, IL6ST, IL6, IL4, IL2RA, IL2, IL1B, IFNA1, ICAM1, HMOX1, HIF1A, HGF, GRB2, FN1, AKT1, F3, CCR5

Signal transduction

1.40787E−45

CD34, CD4, ADIPOQ, CASR, TNFRSF10A, TNFSF10, CALCR, VEGFA, SCGB1A1, TTR, TLR4, TIMP1, TIE1, SRI, SPP1, SOX9, SHC1, CCL5, CCL2, BCR, OPN1SW, TNFRSF17, S100A6, RET, PTHLH, PRL, PPARG, POMC, PLXNA2, ATM, TNFRSF11B, NGF, NFKB1, NR3C2, MAS1, LTA, LEP, KIT, JAK2, FASLG, FAS, IRS1, INS, IL18, IL10, IL8RB, IL8, IL6ST, IL6, IL4, IL1B, IGFBP2, IGFBP1, IGF1, IFNA1, ANXA5, HIF1A, GSK3B, ABR, GNB3, GH1, GAS6, GAST, FLNB, AKT1, ESR1, EPO, EPAS1, AGTR1, EGF, RAPH1, RETN, ADRBK1, ADRB2, CD244, ADM, CCR5

Negative regulation of apoptotic process

5.31297E−44

CDKN1A, CD44, CD40LG, CD28, CAT, CASP3, WT1, VHL, VEGFA, UCP2, TP53, TIMP1, TAF9, AURKA, SOX9, SOD2, SOD1, SHC1, BCL2, RELA, OPA1, NGF, NFKB1, MPO, MMP9, SMAD3, LRP1, LEP, KDR, FAS, IL10, IL6ST, IL6, IL4, IL2, IGF1, HSPD1, HSPA5, ANXA5, HIF1A, HGF, HDAC2, GSK3B, GAS6, AKR1B1, ALB, AKT1, EPO, ITCH, DPEP1, GHRL

Positive regulation of gene expression

4.56741E−41

CDKN2A, CD34, CD28, CASR, TNFSF11, CALCR, FGF23, WT1, VIM, VEGFA, VDR, TP53, TNF, TLR4, TGFB1, SOX9, BMP2, RET, PLAG1, PF4, ATM, NOS3, NGF, MSN, SMAD3, SMAD2, KIT, APP, INS, IL18, IL8, IL6, IL4, IL1B, APOB, IGF1, IFNG, HIF1A, GSN, GSK3B, AMH, GAS6, FN1, AKT1, F3, ENG, EGF, CRP

Response to drug

5.19875E−39

CDKN1A, ADIPOQ, CAT, CASP3, XRCC1, UMOD, SCGB1A1, TP53, HNF1B, SST, SOD2, SOD1, BGLAP, BCL2, BCHE, RET, REN, RELA, PTH, PPARG, ABCB1, TNFRSF11B, MTHFR, MAS1, LTA, LPL, RHOA, IL10, IGFBP2, APOA1, ICAM1, APEX1, HSPD1, HMOX1, HDAC2, AMH, FABP3, ENG, EDN1

Positive regulation Of transcription by RNA polymerase II

7.65307E−37

CDKN2A, CD40, CD28, RUNX2, TP63, TNFSF11, CNBP, WT1, VEGFA, VDR, TP53, TNF, TLR4, TGFB1, HNF1B, TAF9, SOX9, BMP2, RELA, REL, PTH, PPARG, PPARA, POMC, PLAG1, PF4, PER1, SERPINE1, ATM, NOS1, NODAL, NFKB1, MAX, SMAD4, SMAD3, SMAD2, IRF1, APP, IL18, IL17A, IL10, IL6, IL4, IL2, IGF1, APEX1, HNF4A, HIF1A, HGF, HDAC2, AKT1, ESR1, EPAS1, ENG, MIXL1, BCL2L12, EDN1, DDIT3, ADRB2

Inflammatory response

1.72781E−35

CD44, CD40LG, CD40, CALCA, UMOD, TNFRSF1B, TNF, TLR4, TGFB1, TAC1, SPP1, BMP2, SELP, CCL5, CCL2, RELA, REL, PTGS2, PF4, NFKB1, MEFV, KNG1, KIT, IDO1, IL18, IL17A, IL8RB, IL8, IL6, IL2RA, IL1B, HSPG2, AKT1, AGTR1, ITCH, AGER, DPEP1, F11R, CRP, ADM, CC5

Response to lipopolysaccharide

2.05775E−34

CASP3, VCAM1, UMOD, SCGB1A1, TNFRSF1B, TLR4, THBD, TFPI, TAC1, SOD2, SELP, REN, RELA, NOS3, NOS1, MPO, LTA, JAK2, FASLG, IDO1, IL10, IL1B, APOB, ICAM1, HSPD1, HDAC2, GGT1, EPO, EDN1, CYP27B1, ADM

Cellular protein metabolic process

5.1266E−34

CALCA, FGF23, TTR, TIMP1, TF, SPP1, SAA1, PRL, SERPINA1, P4HB, NPPA, MMP2, MMP1, KNG1, APP, INS, APOE, IL6, APOB, IGFBP3, IGFBP2, IGFBP1, IGF1, APOA1, HSPG2, GSN, GAS6, FN1, ALB, AHSG, CST3, CP

Response to hypoxia

4.716E−33

ADIPOQ, CAT, CASP3, XRCC1, VEGFA, VCAM1, UCP2, BMP2, SOD2, PPARA, ATM, NOS1, MTHFR, MMP2, SMAD4, SMAD3, LTA, RHOA, LEP, ICAM1, HSPD1, HMOX1, HIF1A, EPO, EPAS1, ENG, EDN1, AGER, HIF3A, ADM