Table 2 Top 10 enriched KEGG pathways assigned to the text mining genes

Pathways in cancer

2.40582E−63

CDKN2A, CDKN1A, CASP3, FGF23, VHL, VEGFA, TP53, TGFB1, BMP2, BCR, BCLBAX, RET, RELA, PTGS2, PPARG, NOTCH3, NFKB1, MMP9, MMP2, MMP1, MAX, SMAD4, SMAD3, SMAD2, RHOA, KNG1, KIT, JAK2, FASLG, FAS, IL8, IL6ST, IL6, IL4, IL2RA, IL2, IGF1, IFNG, IFNA1, HMOX1, HIF1A, HGF, HDAC2, GSTT1, GSTM1, GSK3B, GRB2, GNB3, FN1, AKT1, ESR1, EPO, EPAS1, AGTR1, AGT, EGF, EDN1

Cytokine-cytokine receptor interaction

9.03679E−52

CD40LG, CD40, CD4, TNFRSF10A, TNFSF10, TNFSF11, TNFRSF1B, TNF, TGFB1, BMP2, CCL5, CCL2, TNFRSF17, PRL, PF4, TNFRSF11B, NODAL, NGF, LTA, LEP, FASLG, FAS, IL18, IL17A, IL10, IL8RB, IL8, IL6ST, IL6, IL4, IL2RA, IL2, IL1B, IFNG, IFNA1, AMH, GH1, EPO, CCR5

AGE-RAGE signaling pathway in diabetic complications

1.20609E−43

CASP3, VEGFA, VCAM1, TNF, THBD, TGFB1, CCL2, BCL2, BAX, RELA, SERPINE1, NOS3, NFKB1, MMP2, SMAD4, SMAD3, SMAD2, JAK2, IL8, IL6, IL1B, ICAM1, FN1, AKT1, F3, AGTR1, AGT, EDN1, AGER

PI3K-Akt signaling pathway

1.90881E−39

CDKN1A, FGF23, YWHAE, VWF, VEGFA, TSC2, TP53, TLR4, SPP1, BCL2, RELA, PRL, NOS3, NGF, NFKB1, KIT, KDR, JAK2, FASLG, IRS1, INS, IL6, IL4, IL2RA, IL2, IGF1, IFNA1, HGF, GSK3B, GRB2, GNB3, GH1, FN1, AKT1, EPO, EGF

HIF-1 signaling pathway

6.07415E−36

CDKN1A, VHL, VEGFA, TLR4, TIMP1, TF, BCL2, RELA, EPO, SERPINE1, NPPA, NOS3, NFKB1, INS, IL6, IGF, IFNG, HMOX1, HIF1A, GAPDH, AKT1, ENO2, ENO1, EGF, EDN1

Metabolic pathways

7.22668E−35

PHGDH, CEL, HPSE, KL, CAT, TKTL1, UROD, TYRP1, SCD, SAT1, ACSM3, RENBP, PTGS2, PIK3C2A, PAH, NOS3, NOS1, NEU1, NAGLU, MTHFR, ARG2, LBR, IDO1, HSD11B1, HMOX1, ACACA, GSTT1, GSTM1, GSR, GLA, GGT1, GAPDH, FUT2, AKR1B1, ALDH2, ENO2, ENO1, CNDP1, DPYD, CYP27B1, CYP3A5, CHDH, CYP3A4, COMT

Proteoglycans in cancer

9.0523E−32

HPSE, CDKN1A, CD63, CD44, CASP3, VEGFA, TP53, TNF, TLR4, TGFB1, MSN, MMP9, MMP2, SMAD2, RHOA, KDR, FASLG, FAS, IGF1, HSPG2, HIF1A, HGF, GRB2, FN1, FLNB, AKT1, ESR1

Transcriptional misregulation in cancer

2.446E−31

CDKN1A, CD40, RUNX2, WT1, TP53, BAX, RELA, REL, PPARG, PLAT, ATM, NFKB1, MPO, MMP9, MMP3, MAX, ITGAM, IL8, IL6, IGFBP3, IGF1, HDAC2, GZMB, EYA1, DDIT3

Fluid shear stress and atherosclerosis

2.08996E−29

VEGFA, VCAM1, TP53, TNF, THBD, CCL2, BCL2, RELA, PLAT, NOS3, NFKB1, MMP9, MMP2, RHOA, KDR, IL1B, IFNG, ICAM1, HMOX1, GSTT1, GSTM1, AKT1, EDN1

Human cytomegalovirus infection

8.37841E−29

CDKN2A, CDKN1A, CASP3, VEGFA, TSC2, TP53, TNF, CCL5, CCL2, BAX, RELA, PTGS2, NFKB1, RHOA, FASLG, FAS, IL8RB, IL8, IL6, IL1B, IFNA1, GSK3B, GRB2, GNB3, AKT1, CCR5