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Table 4 Details of the 34 drugs that potentially target of the 26 core genes

From: Identification of core genes and pathways between geriatric multimorbidity and renal insufficiency: potential therapeutic agents discovered using bioinformatics analysis

Number

Drug

Genes

Interaction

Score

Drug class

Approved?

PubMed ID

1

BUROSUMAB

FGF23

antagonist

255.17

Not available

NO

29545670

2

ADEMETIONINE

TF

N/A

15.95

Not available

NO

None found

3

ADALIMUMAB

TF

N/A

3.75

Not available

Yes*

27115882

4

CAPLACIZUMAB

VWF

inhibitor

13.67

Antibody fragment

NO

None found

5

SILTUXIMAB

IL6

antagonist

10.21

Therapeutic antibodies

Yes*

8823310

6

LEVOFLOXACIN

IL6

N/A

1.28

Not available

NO

12714806

7

METRONIDAZOLE

IL6

N/A

1.28

Not available

NO

12111578

8

RANIBIZUMAB

VEGFA

inhibitor

8.81

Antibody fragment

Yes*

18046235

9

PEGAPTANIB SODIUM

VEGFA

antagonist

3.36

Aptamer

Yes*

23953100

10

AFLIBERCEPT

VEGFA

antibody

2.35

Therapeutic antibodies/fusion protein

NO

22813448

11

LOMITAPIDE MESYLATE

P4HB

inhibitor

3.54

Not available

Yes*

None found

12

CALCITONIN

SPP1

N/A

3.54

Small molecule

Yes*

8013390

13

CETUXIMAB

EGF

N/A

3.38

Therapeutic antibodies

Yes*

25677871

14

DEFIBROTIDE

SERPINE1

N/A

3.19

Not available

Yes*

12745658

15

UROKINASE

SERPINE1

inducer

3.19

Thrombolytic agents/protein

Yes*

12709915

16

CETRORELIX

SERPINE1

N/A

2.13

Fertility agents/peptide

Yes*

16391860

17

GADOFOSVESET

ALB

N/A

3.04

Not available

NO

None found

18

IODIPAMIDE

ALB

N/A

3.04

Not available

NO

None found

19

OLMESARTAN MEDOXOMIL

ALB

N/A

3.04

Not available

NO

22086979

20

CHOLESTYRAMINE

APOB

N/A

2.36

Not available

Yes*

3906004

21

MIPOMERSEN

APOB

N/A

1.77

Antisense oligo

Yes*

None found

22

RIBAVIRIN

CST3

N/A

1.93

Not available

Yes*

18637076

23

DIGOXIN

CST3

N/A

1.88

Cardiotonic agents/small Molecule

Yes*

17698593

24

GANCICLOVIR

APOE

N/A

1.88

Not available

Yes*

16322528

25

SOYBEAN OIL

APOE

N/A

1.5

Not available

Yes*

3021887

26

WARFARIN

GAS6

N/A

1.77

Anticoagulants/small molecule

Yes*

16014032

27

GLUCAGON

APOA1

N/A

1.59

Not available

Yes*

3130065

28

DEXRAZOXANE

CP

N/A

1.52

Not available

Yes*

8285144

29

PENICILLAMINE

CP

N/A

1.3

Not available

Yes*

11721763

30

OCRIPLASMIN

FN1

cleavage

1.29

Not available

Yes*

23193358

31

IMATINIB MESYLATE

HGF

N/A

0.91

Not available

NO

11439348

32

RAMIPRIL

TGFB1

N/A

0.86

Antihypertensive agents

Yes*

15716710

33

FLUOROURACIL

IGFBP3

N/A

0.61

Not available

Yes*

20860465

34

HYDROXYCHLOROQUINE

APP

N/A

0.37

Small molecule

Yes*

11117548

  1. Interaction: The nature of drug interaction with target genes
  2. Score: Drug interaction scores with target genes
  3. Approved?: (Yes*) Drugs that have been approved by the US Food and Drug Administration
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BMC Medical Genomics

ISSN: 1755-8794

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