Table 3 The enrichment result of KEGG pathway of the top10 degree genes and module genes in PPI network
ID | Description | Count | P value | Genes | |
|---|---|---|---|---|---|
PPI-degree top 10 | hsa05020 | Prion diseases | 3 | 4.49E-06 | IL6/C1QA/C1QB |
hsa05133 | Pertussis | 3 | 4.73E-05 | IL6/C1QA/C1QB | |
hsa05142 | Chagas disease (American trypanosomiasis) | 3 | 1.17E-04 | IL6/C1QA/C1QB | |
hsa05143 | African trypanosomiasis | 2 | 5.96E-04 | IL6/VCAM1 | |
hsa05144 | Malaria | 2 | 1.05E-03 | IL6/VCAM1 | |
hsa05150 | Staphylococcus aureus infection | 2 | 2.01E-03 | C1QA/C1QB | |
hsa04610 | Complement and coagulation cascades | 2 | 2.70E-03 | C1QA/C1QB | |
hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2 | 4.29E-03 | IL6/VCAM1 | |
hsa04668 | TNF signaling pathway | 2 | 5.17E-03 | IL6/VCAM1 | |
hsa05322 | Systemic lupus erythematosus | 2 | 7.47E-03 | C1QA/C1QB | |
hsa05162 | Measles | 2 | 8.03E-03 | IL6/MX1 | |
hsa05160 | Hepatitis C | 2 | 1.00E-02 | LDLR/MX1 | |
hsa05164 | Influenza A | 2 | 1.16E-02 | IL6/MX1 | |
hsa04060 | Cytokine–cytokine receptor interaction | 2 | 3.38E-02 | IL6/TNFRSF11B | |
Module | hsa05020 | Prion diseases | 2 | 2.87E-04 | C1QA/C1QB |
hsa05150 | Staphylococcus aureus infection | 2 | 1.09E-03 | C1QA/C1QB | |
hsa05133 | Pertussis | 2 | 1.36E-03 | C1QA/C1QB | |
hsa04610 | Complement and coagulation cascades | 2 | 1.46E-03 | C1QA/C1QB | |
hsa05142 | Chagas disease (American trypanosomiasis) | 2 | 2.48E-03 | C1QA/C1QB | |
hsa05322 | Systemic lupus erythematosus | 2 | 4.09E-03 | C1QA/C1QB |