Lack of causal association between heart failure and osteoporosis: a Mendelian randomization study

BMC Medical Genomics

Table 1 Detailed information of studies and datasets used for analyses

Phenotype	Data source	Sample size	Adjustment	Population
Heart Failure [25]	HERMES consortium	977,323	Principal components in individual studies	European
FA-BMD [22]	GEFOS consortium	8143	Sex, age, age², weight	European
FN-BMD [22]	GEFOS consortium	32,735	Sex, age, age², weight
LS-BMD [22]	GEFOS consortium	28,498	Sex, age, age², weight
HE-BMD [23]	UK Biobank	426,824	Age, sex, genotyping array, assessment center and ancestry informative principal components 1 to 20	European
Fracture [23]	UK Biobank and 23andMe cohorts	1,214,434	Age, sex, genotyping array, assessment center and ancestry informative principal components 1 to 20	European

FA-BMD, forearm bone mineral density; FN-BMD, femoral neck bone mineral density; LS-BMD, lumbar spine bone mineral density; HE-BMD, heel bone mineral density; HERMES, Heart Failure Molecular Epidemiology for Therapeutic Targets; GEFOS, Genetic Factors for Osteoporosis

ISSN: 1755-8794