Alterations of DNA methylation and expression of genes related to thyroid hormone metabolism in colon epithelium of obese patients

Table 4 Relationship between methylation levels and demographic/lifestyle factors of the study participants in DIO3 gene

Characteristics	DIO3 methylation%
Characteristics	β^A	P value*
Age	− 0.145	0.384
Consumption of vitamin B supplement	0.027	0.872
Consumption of calcium supplement	0.003	0.987
Consumption of vitamin D supplement	− 0.085	0.611
NSAID use	− 0.123	0.460
Consumption of Omega 3 fatty acids supplement	0.399	0.013
Colon Cancer family history	0.128	0.442
Cancer family history	0.142	0.395
Alcohol consumption	− 0.062	0.712
Red meat consumption
< 2/week	Reference
2–3/week	0.293	0.231
> 3/week	0.300	0.220
Smoking
Never smoking	Reference
Smoker	− 0.192	0.248

NSAID, Non-steroidal Anti-inflammatory Drugs
*Simple linear regression was used to study the linear relationship between variables
^Aβ refers to the standardized coefficient

ISSN: 1755-8794