Fig. 1
Transcriptomic characteristics of patients with HBV-LC. A Study design and flow chart of the network-based analysis strategy. B Volcano and PCA plots of the DE mRNAs (log2 |FC|≥1, padj ≤ 0.05) in the three pairwise comparison groups. C Volcano and PCA plots of the DE miRNAs (p ≤ 0.05) in the three pairwise comparison groups. D Heatmap showing the expression levels of the 442 mRNAs in the three pairwise comparison groups of PBMCs. E Heatmap showing the expression levels of the 158 mRNAs in the three pairwise comparison groups of PBMCs. Numbers of paired miRNA/mRNA sequencing samples (n = 9, 12, and 12 in the LC, CHB, and NC groups, respectively). CHB Chronic hepatitis B; DE Differentially expressed; LC Liver cirrhosis; NC Normal control; PBMC Peripheral blood mononuclear cell