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Fig. 2 | BMC Medical Genomics

Fig. 2

From: MiRNA/mRNA network topology in hepatitis virus B-related liver cirrhosis reveals miR-20a-5p/340-5p as hubs initiating fibrosis

Fig. 2

Identification and functional analysis of the core module in miRNA/mRNA network. A Flow chart of the identification of the miRNA/mRNA network and the core module. B Network layout of the core module containing four miRNAs and 75 mRNAs (the top 99 miRNA/mRNA pairs; the RGPD/miR-340-5p and SERTAD2/miR-93-5p pairs were not included, as shown in gray). C Expression levels of miRNA sequencing of the four miRNAs in the core module. D Heatmap showing the expression levels of the 75 mRNAs in the core module. E Dot plot showing the results of functional analysis of the core module in the comparison between different stages of the disease. Numbers of paired miRNA/mRNA sequencing samples (n = 9, 12, and 12 in the LC, CHB, and NC groups, respectively). CHB Chronic hepatitis B; DE Differentially expressed; LC Liver cirrhosis; NC Normal control; PBMC Peripheral blood mononuclear cell. **padj < 0.01, *padj < 0.05

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