Fig. 3

Transcriptional differences and pathway analysis of hub miRNAs. A Network layout of the two hub nodes (miR-20a-5p and miR-340-5p) and the 75 mRNAs in the core module. B Changes in the expression of the core module mRNAs connecting to miR-20a-5p in the PBMC comparison groups. C Changes in the expression of the core module mRNAs connecting to miR-340-5p in the PBMC comparison groups. D Changes in the expression of the core module mRNAs connecting to both miR-20a-5p and miR-340-5p in the PBMC comparison groups. E, F, G Pie charts of the magnitude of different functional categories of three groups (E: both connected, F: miR-20a-5p connected, G: miR-340-5p connected) of connected mRNAs in the core module. Numbers of paired miRNA/mRNA sequencing samples (n = 9, 12, and 12 in the LC, CHB, and NC groups, respectively). CHB Chronic hepatitis B; DE Differentially expressed; LC Liver cirrhosis; NC Normal control; PBMC Peripheral blood mononuclear cell