CYP4 subfamily V member 2 (CYP4V2) polymorphisms were associated with ischemic stroke in Chinese Han population

BMC Medical Genomics

Table 5 False-positive report probability values for the associations between CYP4V2 polymorphisms and IS susceptibility

SNP ID	OR (95% CI)	p	Statistical power	Prior probability
SNP ID	OR (95% CI)	p	Statistical power	0.25	0.1	0.01	0.001	0.0001
Overall
rs1398007	1.34 (1.05–1.71)	0.009	0.818	0.064	0.170	0.693	0.958	0.996
Age < 60 years
rs1398007	1.64 (1.06–2.56)	0.028	0.809	0.098	0.247	0.783	0.973	0.997
Males
rs1398007	1.37 (1.01–1.88)	0.040	0.686	0.177	0.393	0.877	0.986	0.999
rs1053094	1.80 (1.08-3.00)	0.029	0.657	0.099	0.248	0.784	0.973	0.997
	1.40 (1.03–1.91)	0.030	0.668	0.132	0.312	0.833	0.981	0.998
	1.34 (1.06–1.68)	0.014	0.836	0.039	0.108	0.570	0.930	0.993
rs56413992	1.33 (1.01–1.75)	0.045	0.805	0.134	0.318	0.837	0.981	0.998
Non-smokers
rs1398007	1.51 (1.06–2.14)	0.010	0.943	0.061	0.164	0.683	0.956	0.995
Non-drinkers
rs1398007	1.66 (1.17–2.37)	0.004	0.847	0.018	0.053	0.381	0.861	0.984
rs1398007	1.45 (1.03–2.03)	0.026	0.578	0.136	0.321	0.839	0.981	0.998
IS patients with HYP vs. Controls
rs1398007	1.50 (1.14–1.96)	0.008	0.982	0.009	0.026	0.230	0.751	0.968
rs1398007	1.40 (1.08–1.82)	0.010	0.697	0.049	0.134	0.629	0.945	0.994
IS patients without HYP vs. Controls
rs1398007	0.37 (0.15–0.88)	0.031	0.248	0.229	0.471	0.907	0.990	0.999
IS patients with HYP vs. without HYP
rs1398007	2.63 (1.05–6.61)	0.035	0.280	0.298	0.561	0.934	0.993	0.999
	1.49 (1.04–2.13)	0.030	0.515	0.083	0.214	0.750	0.968	0.997
	1.48 (1.09–2.02)	0.011	0.971	0.040	0.111	0.579	0.933	0.993

Bold indicate that level of false-positive report probability < 0.2
Statistical power was calculated using the number of observations in the subgroup and the OR and p values in this table. The level of false-positive report probability threshold was set at 0.2, and noteworthy findings are presented

ISSN: 1755-8794