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Table 4 Association between PNPLA3 polymorphisms and HCC susceptibility stratified by age

From: Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

SNP_ID

Model

Genotype

Age > 55

Age ≤ 55

Case

Control

OR (95% CI)

p

FDR-p

Case

Control

OR (95% CI)

p

FDR-p

rs738409

Co-dominant

CC

72

90

1

  

82

90

1

  

CG

122

106

1.53(1.01–2.32)

0.046

0.046

128

134

1.04(0.71–1.53)

0.843

1.124

GG

36

29

1.62(0.89–2.94)

0.114

0.227

43

33

1.42(0.82–2.44)

0.212

0.212

Dominant

CC

72

90

1

  

82

90

1

  

CG + GG

158

135

1.55(1.04–2.30)

0.030

0.030

171

167

1.11(0.77–1.61)

0.565

0.754

Recessive

CC + CG

194

196

1

  

210

224

1

  

GG

36

29

1.27(0.74–2.19)

0.390

1.599

43

33

1.38(0.84–2.26)

0.198

0.198

Log-additive

–

–

–

1.33(1.00–1.76)

0.047

0.063

–

–

1.16(0.89–1.50)

0.276

0.368

rs3747207

Co-dominant

GG

72

90

1

  

84

91

1

  

GA

126

108

1.57(1.04–2.37)

0.034

0.045

128

140

0.98(0.67–1.44)

0.926

0.926

AA

33

28

1.50(0.82–2.75)

0.192

0.192

41

30

1.47(0.84–2.57)

0.178

0.237

Dominant

GG

72

90

1

  

84

91

1

  

GA + AA

159

136

1.55(1.05–2.30)

0.029

0.039

169

170

1.07(0.74–1.54)

0.726

0.726

Recessive

GG + GA

198

198

1

  

212

231

1

  

AA

33

28

1.16(0.66–2.03)

0.605

0.605

41

30

1.48(0.89–2.47)

0.128

0.170

Log-additive

–

–

–

1.31(0.98–1.74)

0.066

0.066

–

–

1.15(0.88–1.50)

0.294

0.294

rs4823173

Co-dominant

GG

70

90

1

  

82

94

1

  

GA

129

109

1.62(1.07–2.45)

0.023

0.046

127

133

1.09(0.74–1.60)

0.673

2.692

AA

31

26

1.62(0.86–3.00)

0.137

0.183

44

30

1.66(0.96–2.88)

0.072

0.289

Dominant

GG

70

90

1

  

82

94

1

  

GA + AA

160

135

1.62(1.09–2.40)

0.018

0.036

171

163

1.19(0.83–1.72)

0.348

1.394

Recessive

GG + GA

199

199

1

  

209

227

1

  

AA

31

26

1.21(0.68–2.15)

0.515

1.030

44

30

1.58(0.96–2.61)

0.074

0.297

Log-additive

–

–

–

1.36(1.02–1.82)

0.040

0.079

–

–

1.24(0.95–1.61)

0.109

0.435

rs2896019

Co-dominant

TT

68

92

1

  

82

94

1

  

TG

129

105

1.78(1.17–2.70)

0.007

0.028

128

136

1.07(0.73–1.57)

0.719

1.437

GG

34

29

1.67(0.91–3.05)

0.098

0.391

42

31

1.54(0.89–2.68)

0.124

0.249

Dominant

TT

68

92

1

  

82

94

1

  

TG + GG

163

134

1.75(1.18–2.61)

0.006

0.023

170

167

1.16(0.80–1.67)

0.428

0.855

Recessive

TT + TG

197

197

1

  

210

230

1

  

GG

34

29

1.19(0.69–2.06)

0.539

0.719

42

31

1.48(0.89–2.44)

0.127

0.254

Log-additive

–

–

–

1.40(1.05–1.86)

0.022

0.086

–

–

1.20(0.92–1.60)

0.172

0.344

  1. HCC hepatocellular carcinoma; SNP single nucleotide polymorphism; OR odds ratio; 95% CI 95% confidence interval; FDR false discovery rate
  2. p-value was calculated by logistic regression analysis with adjustments for age, gender and smoking
  3. Bold values indicate statistical significance
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BMC Medical Genomics

ISSN: 1755-8794

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