Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

Table 5 Association of PNPLA3 gene polymorphisms with serum tumor marker levels

SNP_ID	Genotype	CEA (ng/mL)		AFP (ng/mL)		CA 50 (U/mL)		CA 125 (U/mL)		CA 199 (U/mL)
SNP_ID	Genotype	n	Mean ± SE	n	Mean ± SE	n	Mean ± SE	n	Mean ± SE	n	Mean ± SE
rs738409	CC	62	14.40 ± 0.80	49	41.50 ± 10.64	62	8.32 ± 1.34	47	143.46 ± 35.02	59	54.11 ± 10.36
	CG	98	15.54 ± 1.13	81	178.10 ± 103.35	78	7.54 ± 0.97	72	89.20 ± 17.13	92	51.50 ± 8.13
	GG	28	11.86 ± 1.48	21	1237.33 ± 790.25	20	10.30 ± 2.94	23	142.37 ± 41.92	28	62.71 ± 20.45
	p		0.391		0.007		0.543		0.245		0.826
rs3747207	GG	64	14.12 ± 0.80	49	41.50 ± 10.64	62	8.32 ± 1.34	49	138.79 ± 33.73	61	53.70 ± 10.03
	GA	99	15.87 ± 1.73	83	318.43 ± 174.55	79	7.84 ± 1.01	73	88.15 ± 16.92	93	52.06 ± 8.06
	AA	26	12.37 ± 1.55	20	699.20 ± 608.41	20	10.30 ± 2.94	21	153.15 ± 45.27	26	64.34 ± 22.00
	p		0.440		0.256		0.629		0.218		0.801
rs4823173	GG	61	14.36 ± 0.82	48	42.77 ± 10.83	61	8.45 ± 1.36	47	157.30 ± 36.60	59	54.53 ± 10.35
	GA	98	14.59 ± 1.13	82	321.99 ± 176.66	78	7.51 ± 0.97	71	81.00 ± 15.31	91	51.55 ± 8.22
	AA	29	11.86 ± 1.43	21	666.08 ± 579.66	21	9.93 ± 2.83	24	137.30 ± 40.35	29	61.33 ± 19.78
	p		0.373		0.284		0.598		0.086		0.86
rs2896019	TT	59	14.21 ± 0.85	46	95.18 ± 57.40	59	8.66 ± 1.40	46	158.12 ± 37.43	58	54.62 ± 10.53
	TG	101	16.08 ± 1.70	85	284.68 ± 168.21	81	7.70 ± 0.99	73	80.97 ± 14.89	93	52.18 ± 8.060
	GG	29	11.52 ± 1.33	21	660.54 ± 579.94	21	9.82 ± 2.84	24	136.13 ± 40.52	29	61.02 ± 19.80
	p		0.250		0.377		0.663		0.082		0.884

SNP single nucleotide polymorphism; CEA carcino-embryonic antigen; AFP alpha-fetoprotein; CA 50 carbohydrate antigen 50; CA 125 carbohydrate antigen 125; CA 199 carbohydrate antigen 199; n number; SE standard error
Bold values indicate statistical significance
p-values were calculated using χ² tests

ISSN: 1755-8794