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Table 7 SNP-SNP interaction models of candidate SNPs analyzed by the MDR method

From: Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

Model

Training Bal. Acc

Testing Bal. Acc

CVC

OR (95% CI)

p

rs2896019

0.536

0.536

10/10

1.37 (1.05–1.79)

0.021

rs738409,rs4823173

0.539

0.527

6/10

1.39(1.06–1.81)

0.015

rs738409,rs4823173,rs2896019

0.523

0.523

9/10

1.45(1.11–1.89)

0.007

rs738409,rs3747207,rs4823173,rs2896019

0.546

0.532

10/10

1.48(1.13–1.93)

0.004

  1. SNP single nucleotide polymorphism; MDR multifactor dimensionality reduction; Bal. Acc. balanced accuracy; CVC cross-validation consistency; OR odds ratio; 95% CI 95% confidence interval
  2. Bold values indicate statistical significance
  3. p-values were calculated using χ2 tests
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BMC Medical Genomics

ISSN: 1755-8794

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