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Table 8 FPRP analysis of significant findings

From: Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

SNP_ID

Genotype

Crude OR (95% CI)

p

Statistical power

Prior probability

0.25

0.1

0.01

0.001

0.0001

rs738409

Overall analysis

G versus C

1.21(1.00–1.45)

0.039

0.990

0.106

0.261

0.796

0.975

0.997

GG versus CC

1.49(1.00–2.22)

0.045

0.500

0.213

0.448

0.899

0.989

0.999

Log-additive

1.22(1.01–1.48)

0.044

0.982

0.118

0.286

0.815

0.978

0.998

Age > 55

CG versus CC

1.53(1.01–2.32)

0.045

0.163

0.227

0.468

0.906

0.990

0.999

CG + GG versus CC

1.55(1.04–2.30)

0.030

0.435

0.169

0.379

0.870

0.985

0.999

Log-additive

1.33(1.00–1.76)

0.046

0.800

0.147

0.341

0.851

0.983

0.998

rs3747207

Age > 55

GA versus GG

1.57(1.04–2.37)

0.032

0.414

0.187

0.409

0.884

0.987

0.999

GA + AA versus GG

1.55(1.05–2.30)

0.030

0.435

0.169

0.379

0.870

0.985

0.999

rs4823173

Overall analysis

A versus G

1.25(1.04–1.50)

0.016

0.975

0.048

0.132

0.625

0.944

0.994

AA versus GG

1.63(1.08–2.46)

0.020

0.346

0.148

0.342

0.851

0.983

0.998

GA + AA versus GG

1.35(1.04–1.77)

0.030

0.777

0.103

0.257

0.792

0.975

0.997

Log-additive

1.28(1.06–1.55)

0.011

0.948

0.035

0.098

0.545

0.924

0.992

Age > 55

GA versus GG

1.62(1.07–2.45)

0.022

0.358

0.157

0.359

0.860

0.984

0.998

GA + AA versus GG

1.62(1.09–2.40)

0.016

0.351

0.121

0.293

0.820

0.979

0.998

Log-additive

1.36(1.02–1.82)

0.039

0.745

0.134

0.318

0.837

0.981

0.998

rs2896019

overall analysis

G versus T

1.25(1.04–1.50)

0.016

0.975

0.048

0.132

0.625

0.944

0.994

TG versus TT

1.33(1.01–1.76)

0.012

0.856

0.039

0.109

0.574

0.932

0.993

GG versus TT

1.59(1.06–2.39)

0.026

0.390

0.165

0.373

0.867

0.985

0.998

TG + GG versus TT

1.38(1.06–1.81)

0.020

0.727

0.076

0.198

0.731

0.965

0.996

Log-additive

1.28(1.06–1.55)

0.011

0.948

0.035

0.098

0.545

0.924

0.992

Age > 55

TG versus TT

1.78(1.17–2.70)

0.007

0.210

0.087

0.222

0.759

0.969

0.997

TG + GG versus TT

1.75(1.18–2.61)

0.006

0.225

0.075

0.195

0.728

0.964

0.996

Log-additive

1.40(1.05–1.86)

0.020

0.683

0.082

0.211

0.746

0.967

0.997

  1. FPRP False-positive report probability; SNP single nucleotide polymorphism; OR odds ratio; CI confidence interval
  2. FPRP values were less than 0.2, indicating that the positive results were noteworthy
  3. Bold values represent noteworthy findings