Altered DNA methylation of CYP2E1 gene in schizophrenia patients with tardive dyskinesia

BMC Medical Genomics

Table 3 Generalized linear model analysis of DNA methylation levels of three CpG sites in promoter of the CYP2E1 gene

Group	Parameters	Site 1	Site 2	Site 3	Average
TD	Mean ± SD	11.1 ± 10.6	8.7 ± 10.8	6.6 ± 9.6	8.8 ± 10.0
NTD		16.4 ± 12.3	14.3 ± 12.5	12.7 ± 11.0	14.5 ± 11.9
HC		15.9 ± 11.3	15.5 ± 12.1	13.8 ± 10.9	15.1 ± 11.3
Levene’s F Statistics	F	0.045	0.316	0.559	0.199
Levene’s F Statistics	p	0.956	0.730	0.574	0.920
TD vs. NTD vs. HC	F	2.64	3.79	6.23	3.93
TD vs. NTD vs. HC	p	0.0762	0.0258	0.0026*	0.0227
TD vs. HC	t	− 1.89	− 2.58	− 3.33	− 2.57
TD vs. HC	p	0.0615	0.0114*	0.0012*	0.0115*
NTD vs. HC	t	0.19	− 0.45	− 0.59	− 0.33
NTD vs. HC	p	0.8531	0.0657	0.5561	0.7442
TD vs. NTD	t	− 2.08	− 2.13	− 2.74	− 2.25
TD vs. NTD	p	0.0404	0.0355	0.0072*	0.0268

Abbreviations: TD, tardive dyskinesia; NTD, without tardive dyskinesia; HC, health controls; F value is based on the generalized linear model for comparing three groups; t value is based on the generalized linear model for comparing two groups. * p < 0.0167 based on Bonferroni correction

ISSN: 1755-8794