Fig. 1

Characterization of hypoxic risk signature to predict prognosis in GC. A Protein–Protein Interaction network of 200 hypoxia-relevant genes. B Top 50 genes coping with hypoxia. C 11 hypoxia associated genes closely related to OS in GC by univariate Cox regression. D and E Model establishment via LASSO regression. F Construction of a hypoxia risk signature to predict prognosis in GC. G–I Spearman correlation analysis of six hypoxic genes in the TCGA and GEO (GSE84437, GSE15459) databases. J–L Principal Component Analysis (PCA) analysis between the two risk groups based on hypoxic genes (TCGA and GEO)