Fig. 3

Key pathways throughout the progression of patient#009. A Heatmap representing hierarchical clustering of each step of progression (columns) and KEGG cancer-related pathways (rows), analyzed by functional enrichment. The color key and histogram related to p-values are indicated in the upper box. A p-value adjusted by FDR of 0.05 has been selected as a significant threshold. B Tree visualization of phylogenetic distances between each step of progression, according to their SNP and CNV alterations. Subsets: shared germline alterations (SHR germline ALT), shared somatic alterations (SHR somatic ALT), adjacent nevus alterations, CM alterations, LN-mts alterations. All analyses performed are fully described under Methods (Additional file 1)