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Table 2 Primary information for PPARγ rs1801282 C > G, rs3856806 C > T, PPARGC1A rs8192678 C > T, rs2970847 C > T, PPARGC1B rs7732671 G > C, rs17572019 G > A polymorphisms

From: Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population

Genotyped SNPs

PPARγ rs1801282C > G

PPARγ rs3856806C > T

PPARGC1A rs8192678 C > T

PPARGC1A rs2970847 C > T

PPARGC1B rs7732671 G > C

PPARGC1B rs17572019 G > A

Chromosome: position

chr3: 12,393,125

chr3: 12,475,557

chr4: 23,815,662

chr4: 23,815,924

chr5: 149,212,243

chr5: 149,212,471

Function

Missense

Coding-synonymous

Missense

Coding-synonymous

Missense

Missense

Regulome DB scorea

2b

6

5

5

Clinical significancee

Likely-benign

Benign/likely-benign

Benign

MAFb for Chinese in database

0.07

0.25

0.35

0.28

0.09

0.07

MAF in our controls (n = 1476)

0.05

0.22

0.44

0.22

0.06

0.06

P value for HWEc test in our controls

0.881

0.026 d

0.954

0.492

0.497

0.139

Genotyping method

SNPscan

SNPscan

SNPscan

SNPscan

SNPscan

SNPscan

% Genotyping value

99.64%

99.64%

99.64%

99.64%

99.64%

99.53%

  1. Bold indicates statistical significance (P < 0.05)
  2. ahttps://www.regulomedb.org/.
  3. bMAF: minor allele frequency
  4. cHWE: Hardy–Weinberg equilibrium
  5. dThe genotype distribution of rs3856806 variant did not reach HWE
  6. e https://www.ncbi.nlm.nih.gov/snp/