Table 3 Hub genes determined using cytoscape plug-in cytoHubba by five algorithms
Gene | Description | Log2FC | Adjust p value | Regulation |
|---|---|---|---|---|
AKT1 | Serine/threonine kinase 1 | 4.183 | 0.007 | Up |
PSEN1 | Presenilin 1 | 5.0827 | 0.030 | Up |
APP | Amyloid beta precursor protein | 5.3519 | 0.021 | Up |
LRRK2 | Leucine rich repeat kinase 2 | 2.8715 | 0.029 | Up |
SLCO1A2 | Solute carrier organic anion transporter family member 1A2 | 3.9143 | 0.030 | Up |
MYOG | Myogenin | 2.2627 | 0.041 | Up |
MDM2 | MDM2 proto-oncogene | 0.4255 | 0.018 | Up |
LIG4 | DNA ligase 4 | 2.7041 | 0.048 | Up |
XRCC4 | X-ray repair cross complementing 4 | 2.8248 | 0.034 | Up |
CCNB1 | Cyclin B1 | 3.1106 | 0.031 | Up |
ATF3 | Activating transcription factor 3 | 2.7574 | 0.018 | Up |
JAG1 | Jagged canonical Notch ligand 1 | 2.2920 | 0.028 | Up |
RAD9A | RAD9 checkpoint clamp component A | − 4.7490 | 0.019 | Down |
AHR | Aryl hydrocarbon receptor | − 1.6973 | 0.035 | Down |