Table 4 Relationship between these SNPs and the risk of THCA in age subgroup

rs2048722

Allele

G

253

187

1.00

175

272

1.00

TPO

A

247

197

1.08 (0.83–1.45)

0.575

169

190

1.38 (1.04–1.83)

0.026*

Co-dominant

G/G

48

66

1.00

46

80

1.00

G/A

91

121

1.11 (0.70–1.78)

0.653

83

112

1.19 (0.74–1.91)

0.465

A/A

53

63

1.26 (0.74–2.15)

0.388

43

39

1.86 (1.05–3.28)

0.033*

Dominant

G/G

48

66

1.00

46

80

1.00

G/A-A/A

144

184

1.16 (0.75–1.80)

0.498

126

151

1.37 (0.88–2.13)

0.163

Recessive

G/G-G/A

139

187

1.00

129

192

1.00

A/A

53

63

1.18 (0.76–1.81)

0.459

43

39

1.67 (1.02–2.73)

0.041*

Additive

–

–

–

1.12 (0.86–1.47)

0.388

–

–

1.35 (1.02–1.79)

0.039*

rs925489

Allele

T

336

492

1.00

307

272

1.00

PTCSC2

C

50

32

2.29 (1.44–3.64)

 < 0.001**

37

50

1.02 (0.65–1.60)

0.999

Co-dominant

T/T

145

230

1.00

135

188

1.00

C/T

46

32

2.22 (1.34–3.69)

0.002**

37

46

1.12 (0.68–1.82)

0.662

C/C

2

0

–

–

0

2

–

–

Dominant

T/T

145

230

1.00

135

188

1.00

C/T-C/C

48

32

2.30 (1.39–3.81)

0.001**

37

48

1.07 (0.66–1.74)

0.780

Recessive

T/T-C/T

191

262

1.00

172

234

1.00

C/C

2

0

–

–

0

2

–

–

Additive

–

–

–

2.32 (1.42–3.79)

 < 0.001**

–

–

1.02 (0.64–1.63)

0.936

rs4919510

Allele

G

207

277

1.00

197

250

1.00

SEMA4G

C

179

243

0.99 (0.76–1.29)

0.946

147

220

0.85 (0.64–1.12)

0.255

Co-dominant

G/G

57

77

1.00

61

58

1.00

C/G

93

123

1.01 (0.65–1.57)

0.962

75

134

0.52 (0.33–0.83)

0.006**

C/C

43

60

0.98 (0.58–1.66)

0.935

36

43

0.80 (0.45–1.42)

0.442

Dominant

G/G

57

77

1.00

61

58

1.00

C/G-C/C

136

183

1.00 (0.66–1.51)

0.998

111

177

0.59 (0.38–0.91)

0.017*

Recessive

G/G-C/G

150

200

1.00

136

192

1.00

C/C

43

60

0.97 (0.62–1.53)

0.901

36

43

1.20 (0.73–1.97)

0.481

Additive

–

–

–

0.99 (0.76–1.29)

0.943

–

–

0.84 (0.63–1.12)

0.241