Table 5 Relationship between these SNPs and the risk of THCA in sex subgroup

rs2048722

Allele

G

100

150

1.00

272

369

1.00

TPO

A

94

122

1.16 (0.80–1.67)

0.442

262

321

1.11 (0.88–1.39)

0.377

Co-dominant

G/G

25

41

1.00

74

102

1.00

G/A

50

68

1.14 (0.59–2.20)

0.687

124

165

1.06 (0.72–1.56)

0.754

A/A

22

27

1.35 (0.61–2.97)

0.463

69

78

1.21 (0.77–1.88)

0.412

Dominant

G/G

25

41

1.00

74

102

1.00

G/A-A/A

72

95

1.20 (0.65–2.23)

0.559

193

243

1.11 (0.78–1.59)

0.569

Recessive

G/G-G/A

75

109

1.00

198

267

1.00

A/A

22

27

1.24 (0.63–2.43)

0.538

69

78

1.16 (0.80–1.69)

0.439

Additive

–

–

–

1.16 (0.78–1.72)

0.464

–

–

1.10 (0.88–1.37)

0.417

rs925489

Allele

T

164

257

1.00

479

657

1.00

PTCSC2

C

30

17

2.77 (1.48–5.17)

0.001**

57

65

1.20 (0.83–1.75)

0.334

Co-dominant

T/T

67

121

1.00

213

297

1.00

C/T

30

15

3.59 (1.74–7.41)

 < 0.001**

53

63

1.19 (0.79–1.80)

0.398

C/C

0

1

–

–

2

1

2.48 (0.22–28.08)

0.463

Dominant

T/T

67

121

1.00

213

297

1.00

C/T-C/C

30

16

3.42 (1.67–6.98)

 < 0.001**

55

64

1.22 (0.81–1.83)

0.345

Recessive

T/T-C/T

97

136

1.00

266

360

1.00

C/C

0

1

–

–

2

1

2.41 (0.21–27.20)

0.478

Additive

–

–

–

3.03 (1.52–6.02)

0.001**

–

–

1.23 (0.83–1.82)

0.303

rs4919510

Allele

G

111

157

1.00

293

370

1.00

SEMA4G

C

83

117

1.00 (0.69–1.46)

0.986

243

346

0.89 (0.71–1.921)

0.295

Co-dominant

G/G

45

34

1.00

84

90

1.00

C/G

67

43

0.88 (0.48–1.64)

0.698

125

190

0.70 (0.48–1.03)

0.067

C/C

25

20

1.01 (0.46–2.19)

0.981

59

78

0.83 (0.53–1.31)

0.421

Dominant

G/G

45

34

1.00

84

90

1.00

C/G-C/C

92

63

0.92 (0.52–1.64)

0.778

184

268

0.74 (0.52–1.06)

0.096

Recessive

G/G-C/G

112

77

1.00

209

280

1.00

C/C

25

20

1.08 (0.54–2.16)

0.821

59

78

1.04 (0.70–1.53)

0.848

Additive

–

–

–

0.99 (0.67–1.45)

0.951

–

–

0.89 (0.71–1.12)

0.340