Table 6 Relationship between these SNPs and the risk of THCA in smoking subgroup

rs2048722

Allele

G

151

230

1.00

221

289

1.00

TPO

A

171

176

1.48 (1.10–1.99)

0.009**

185

267

0.91 (0.70–1.17)

0.451

Co-dominant

G/G

37

71

1.00

62

72

1.00

G/A

77

88

1.65 (0.94–2.90)

0.082

97

145

0.73 (0.47–1.15)

0.172

A/A

47

44

2.14 (1.13–4.06)

0.019*

44

61

0.84 (0.49–1.44)

0.525

Dominant

G/G

37

71

1.00

62

72

1.00

G/A-A/A

124

132

1.81 (1.07–3.06)

0.026*

141

206

0.76 (0.50–1.16)

0.209

Recessive

G/G-G/A

114

159

1.00

159

217

1.00

A/A

47

44

1.57 (0.93–2.67)

0.094

44

61

1.02 (0.65–1.62)

0.924

Additive

–

–

–

1.47 (1.07–2.02)

0.019*

–

–

0.90 (0.69–1.18)

0.455

rs925489

Allele

T

283

387

1.00

360

527

1.00

PTCSC2

C

39

29

1.84 (1.11–3.05)

0.017*

48

53

1.33 (0.88–2.00)

0.180

Co-dominant

T/T

124

180

1.00

156

238

1.00

C/T

35

27

1.48 (0.80–2.74)

0.210

46

51

1.49 (0.94–2.36)

0.092

C/C

2

1

2.48 (0.21–28.77)

0.467

1

1

–

0.109

Dominant

T/T

124

180

1.00

156

238

1.00

C/T-C/C

37

28

1.52 (0.84–2.78)

0.169

48

52

1.46 (0.92–2.32)

0.105

Recessive

T/T-C/T

159

207

1.00

204

289

1.00

C/C

2

1

2.33 (0.20–27.05)

0.500

0

1

–

–

Additive

–

–

–

1.50 (0.86–2.62)

0.154

–

–

1.42 (0.90–2.23)

0.128

rs4919510

Allele

G

181

228

1.00

223

299

1.00

SEMA4G

C

141

188

0.94 (0.70–1.27)

0.704

185

275

0.90 (0.70–1.16)

0.427

Co-dominant

G/G

51

60

1.00

67

75

1.00

C/G

79

108

0.79 (0.47–1.35)

0.391

89

149

0.70 (0.45–1.09)

0.118

C/C

31

40

0.77 (0.39–1.52)

0.453

48

63

0.86 (0.51–1.45)

0.567

Dominant

G/G

51

60

1.00

67

75

1.00

C/G-C/C

110

148

0.79 (0.48–1.30)

0.351

137

212

0.75 (0.50–1.13)

0.171

Recessive

G/G-C/G

130

168

1.00

156

224

1.00

C/C

31

40

0.89 (0.50–1.61)

0.708

48

63

1.07 (0.68–1.67)

0.775

Additive

–

–

–

0.87 (0.62–1.21)

0.407

–

–

0.91 (0.70–1.18)

0.484