Table 7 Relationship between these SNPs and the risk of THCA in drinking subgroup

rs2048722

Allele

G

172

254

1.00

200

265

1.00

TPO

A

168

208

1.19 (0.90–1.58)

0.218

188

235

1.06 (0.81–1.38)

0.667

Co-dominant

G/G

46

74

1.00

53

69

1.00

G/A

80

106

1.08 (0.66–1.78)

0.435

94

127

0.88 (0.55–1.43)

0.612

A/A

44

51

1.39 (0.78–2.46)

0.171

47

54

1.09 (0.62–1.92)

0.765

Dominant

G/G

46

74

1.00

53

69

1.00

G/A-A/A

124

157

1.18 (0.74–1.87)

0.486

141

181

0.95 (0.60–1.48)

0.807

Recessive

G/G-G/A

126

180

1.00

147

196

1.00

A/A

44

51

1.32 (0.81–2.15)

0.266

47

54

1.18 (0.73–1.90)

0.501

Additive

–

–

–

1.17 (0.88–1.56)

0.277

–

–

1.04 (0.78–1.38)

0.808

rs925489

Allele

T

303

451

1.00

340

463

1.00

PTCSC2

C

37

29

1.90 (1.14–3.15)

0.012*

50

53

1.29 (0.85–1.94)

0.231

Co-dominant

T/T

135

211

1.00

145

207

1.00

C/T

33

29

1.69 (0.96–2.99)

0.062

50

49

1.36 (0.84–2.20)

0.212

C/C

2

0

–

–

0

2

–

–

Dominant

T/T

135

211

1.00

145

207

1.00

C/T-C/C

35

29

1.82 (1.04–3.19)

0.036*

50

51

1.29 (0.80–2.07)

0.302

Recessive

T/T-C/T

168

240

1.00

195

256

1.00

C/C

2

0

–

–

0

2

–

–

Additive

–

–

–

1.88 (1.10–3.21)

0.021*

–

–

1.19 (0.75–1.90)

0.463

rs4919510

Allele

G

181

268

1.00

223

259

1.00

SEMA4G

C

159

210

1.21 (0.85–1.48)

0.423

167

253

0.77 (0.59–1.00)

0.049*

Co-dominant

G/G

51

74

1.00

67

61

1.00

C/G

79

120

0.96 (0.60–1.55)

0.875

89

137

0.56 (0.35–0.89)

0.014*

C/C

40

45

1.17 (0.65–2.10)

0.598

39

58

0.60 (0.34–1.05)

0.075

Dominant

G/G

51

74

1.00

67

61

1.00

C/G-C/C

119

165

1.02 (0.65–1.60)

0.927

128

195

0.57 (0.37–0.88)

0.012*

Recessive

G/G-C/G

130

194

1.00

156

198

1.00

C/C

40

45

1.20 (0.72–1.99)

0.483

39

58

0.86 (0.53–1.40)

0.549

Additive

–

–

–

1.07 (0.80–1.43)

0.645

–

–

0.75 (0.56–1.00)

0.049*