Fig. 5

Multiple algorithms identified 4 key genes associated with AD and monocytes. A The PPI network of central genes in the pink and green modules. B A Venn diagram between five algorithms of cytoHubba. The coincident part represents the four genes (KDELR1, SPTAN1, CDC16 and RBBP6) identified by all five algorithms. The lines between nodes in the PPI network diagram represent the interactions between the nodes. C The correlations between 4 key genes and monocytes and AD. D ROC curve of logistic regression model could distinguish AD and control samples. E Confusion matrix of the logistic regression model in test cohort. F ROC curve of the RF model could distinguish AD and control samples. G Confusion matrix of the RF model in test cohort