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Table 1 Effects of genetically predicted Asthma and AD on the risk of RA in the MR analysis

From: Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study

Exposure

Outcome

No. SNPs

MR methods

P

OR

95%CI

Asthma

RA

51

MR Egger

0.020

2.62

1.20–5.72

   

WM

0.042

1.29

1.01–1.66

   

IVW

0.001

1.35

1.13–1.60

   

Simple mode

0.477

1.23

0.70–2.16

   

Weighted mode

0.451

1.24

0.71–2.15

AD

RA

24

MR Egger

0.706

1.03

0.87–1.23

   

WM

0.056

1.12

1.00-1.25

   

IVW

0.019

1.10

1.02–1.19

   

Simple mode

0.230

1.13

0.93–1.36

   

Weighted mode

0.171

1.12

0.96–1.31

  1. MR, Mendelian randomization analysis; SNP, Single nucleotide polymorphism; IVW, Inverse variance weighted; WM, Weighted median; AD, Atopic dermatitis; RA, Rheumatoid arthritis
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