Table 3 Multivariate COX regression reveals the correlation between PHGDH and endometrial cancer survival
Characteristics | Total(N) | HR(95% CI) Univariate analysis | P value Univariate analysis | HR(95% CI) Multivariate analysis | P value Multivariate analysis |
|---|---|---|---|---|---|
Clinical stage | 551 | ||||
Stage I | 341 | Reference | |||
Stage III&Stage IV&Stage II | 210 | 2.527 (1.780–3.587) | < 0.001 | 2.270 (1.462–3.525) | < 0.001 |
Histological type | 527 | ||||
Endometrioid | 409 | Reference | |||
Serous | 118 | 2.125 (1.466–3.081) | < 0.001 | 1.446 (0.887–2.356) | 0.139 |
Histologic grade | 540 | ||||
G1&G2 | 218 | Reference | |||
G3 | 322 | 2.088 (1.391–3.136) | < 0.001 | 1.203 (0.723–2.002) | 0.476 |
Age | 549 | ||||
<=60 | 206 | Reference | |||
> 60 | 343 | 1.353 (0.934–1.961) | 0.110 | ||
Tumor invasion(%) | 473 | ||||
< 50 | 259 | Reference | |||
>=50 | 214 | 1.885 (1.289–2.756) | 0.001 | 1.411 (0.916–2.173) | 0.118 |
PHGDH | 551 | ||||
Low | 275 | Reference | |||
High | 276 | 1.614 (1.132-2.300) | 0.008 | 1.594 (1.027–2.474) | 0.038 |
Menopause status | 505 | ||||
Pre | 35 | Reference | |||
Peri&Post | 470 | 1.530 (0.673–3.477) | 0.310 |