Fig. 1

Colorectal cancer odds ratio and cumulative incidence stratified by carrier and family history status. Individuals stratified for PV carrier status (A + B), and family history (first-degree relative with CRC) (C + D) into three strata based on their polygenic risk score (PRS): Low (< 20% percentile), intermediate (20–80% percentile), or high (> 80% percentile) PRS. The odds ratio (OR) was calculated from a logistic regression model with age, sex, CRC screening status, and the first four principal components of ancestry as covariates. The reference group was non-carriers with intermediate PRS (A), and no family history with intermediate PRS (C). The adjusted OR is indicated by the colored boxes. The numbers next to the ORs indicate the sample size of the corresponding group. The 95% confidence intervals are indicated by the vertical lines around the boxes. Cumulative incidence was estimated from a cox-proportional hazard model using age, sex, family history, CRC screening status, and the first four ancestry principal components as covariates