Skip to main content
Fig. 2 | BMC Medical Genomics

Fig. 2

From: Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

Fig. 2

Interplay of pathogenic variant carrier status, family history, and polygenic risk score. A Colorectal cancer (CRC) odds ratios (ORs) were estimated from logistic models adjusted for age, sex, CRC screening status, and first four ancestry principal components. Non-carriers with intermediate PRS and no family history served as the reference group. B Cumulative incidence was estimated from a cox-proportional hazard model using age, sex, family history, CRC screening status and the first four ancestry principal components as covariates

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us