Fig. 3

Enriched GO terms for case versus control. Detailed GO term enrichment of early and late CTE versus RHI showed concordant neuronal processes and opposite direction of effect for inflammatory processes. A Heatmap of normalized enrichment scores (NES) for enriched GO terms. Row color bar represents significant pathways respective of columns (salmon colored bars to right of dendrogram indicate corresponding NES is FDR < 0.1) Rightmost color bar represents the GO category as listed in the legend. B Number of significant GO terms from A grouped by category. Terms with positive, negative NES (red, blue in A respectively) are plotted as bars to the right and left of 0, respectively. C Significant GO terms from the neuron category in B grouped by subcategory. D Significant GO terms from the immune/inflammation category in B grouped by subcategory