Fig. 5From: Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brainDE and GSEA statistics for genes associated with log AT8. There were many FDR significant DE genes and gene sets associated with AT8 that showed almost complete discordance in direction of effect between RHI + CTE-L and CTE-H. A Log2 fold change estimates of genes associated with AT8 for CTE-L + RHI (Low) and CTE-H (High) sample groups. B Gene set enrichment analysis of GO terms using log2 fold change. Gene sets were discordant if they were significant in both comparisons and are modified in opposite directions. C Clustered heatmap of enriched GO terms for both CTE-H and CTE-L + RHI associated with total years of play at nominal p-value < 0.05 in both. D GO terms from C grouped by category. E Neuron category terms. F Immune/Inflammation category termsBack to article page