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Table 5 Sample statistics

From: Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain

Status

N

Age at Death

Years of Play

log AT8

RIN

(a) All Samples Summary Statistics

RHI

10

49.10 (23.40)

13.62 (11.84)

2.51 (0.30)

6.71 (1.43)

CTE-L

13

52.85 (18.47)

9.08 (5.02)

2.99 (0.72)

6.75 (1.50)

CTE-H

53

74.62 (9.03)

16.08 (7.11)

4.48 (0.78)

6.28 (1.21)

RHI

APOE 1

APOE 0

Total

(b) RHI Risk Variant Groups

TMEM 1

2

3

5

TMEM 0

1

4

5

Total

3

7

10

CTE-L

APOE 1

APOE 0

Total

(c) CTE-L Risk Variant Groups

TMEM 1

2

6

8

TMEM 0

2

3

5

Total

4

9

13

CTE-H

APOE 1

APOE 0

Total

(d) CTE-H Risk Variant Groups

TMEM 1

15

19

34

TMEM 0

8

10

18

Total

23

29

52*

  1. Primary and parenthesized figures are mean and standard deviation for the given covariate, respectively. AT8 is measured in number of chromagenic pixels from histological scan using the AT8 antibody and are log transformed for use in this study. RNA Integrity Number (RIN) of the extracted RNA sample from each brain was assessed by an Agilent Bioanalyzer instrument. A) All sample statistics. Numbers in parentheses are standard deviations. B-D) Sample statistics for each group categorized by risk variants. Athletes with no APOE4 allele were classified as APOE 0 and those with at least one APOE4 allele was classified as APOE 1. Additionally, athletes with a G in TMEM106B rs3173615 were classified as TMEM 0 and for those with homozygous C were classified as TMEM 1. One CTE-H sample was omitted from APOE/TMEM (missing TMEM106B), to keep samples constant between the risk variant study, the same sample was omitted from APOE analysis.