Table 1 Baseline characteristics of included studies
Author, year country | Study design No. of centers | Period of enrollment | Sample size (DM / non-DM) | Type of diabetes | Sample source | Detection method | Reference Gene | circRNA Name |
|---|---|---|---|---|---|---|---|---|
Zhao Z. et al. 2016 (22), China | Prospective cohort, Single-center | July 2015 - June 2016 | 64/60 | T2DM | whole blood | qRT PCR (SYBR) | NR | hsa_circ_0054633 hsa_circ_0068087 |
Wu H. et al. 2019 (23), China | Retrospective Cohort, Single-center | July 2017 - February 2018 | 65/65 | GDM | Maternal serum in the second and third trimester, umbilical cord blood | qRT PCR (SYBR) | Beta actin | hsa_circ_0054633 hsa_circ_063981 hsa_circ_102682 hsa_circ_103410 |
Yang H et al. 2020 (24), China | Prospective cohort, Single-center | April 2015 - July 2016 | 106/ 630 | GDM | Plasma | GoTaq qPCR Master Mix (Promega) on a ViiA 7 Real-time PCR System (Applied Biosystems) | NR | hsa_circ_102893 |
Liang H. et al. 2021 (25), China | Retrospective Cohort, Single-center | January 2018 - March 2019 | 44/44 | T2DM | Serum | qRT PCR (SYBR) | NR | hsa_circ_0054633 |
Yingying Z. et al. 2021 (26), China | Prospective cohort, Single-center | January 2019 - October 2019 | 103/103 | T2DM | whole blood | Both the Prime Script™ RT reagent Kit with gDNA Eraser and Q-PCR kits were equipped with Takara Bio Inc, Japan | GAPDH | hsa_circ_0071106 |