Table 2 Subgroup analysis of the diagnostic performance of circRNA for diabetes diagnosis
Subgroups | Covariates | No. of studies | No. of reports on circRNA accuracy | Pooled sensitivity [95% CI] | P value | Pooled specificity [95% CI] | P value |
|---|---|---|---|---|---|---|---|
Type of circRNA | hsa_circ_0054633 | 3 | 7 | 0.67 [0.53–0.81] | 0.01 | 0.82 [0.63–1.00] | 0.65 |
Other types | 4 | 8 | 0.82 [0.73–0.91] | 0.71 [0.47–0.95] | |||
Study design | Retrospective | 2 | 9 | 0.76 [0.64–0.88] | 0.25 | 0.73 [0.51–0.95] | 0.70 |
Prospective | 3 | 6 | 0.76 [0.63–0.90] | 0.81 [0.60–1.00] | |||
Sample size | ≥ 100 | 4 | 7 | 0.74 [0.61–0.87] | 0.11 | 0.81 [0.62–1.00] | 0.66 |
< 100 | 3 | 8 | 0.78 [0.67–0.90] | 0.71 [0.47–0.96] | |||
Year of publication | ≥ 2020 | 3 | 4 | 0.77 [0.61–0.92] | 0.35 | 0.91 [0.79–1.00] | 0.11 |
< 2020 | 2 | 11 | 0.76 [0.65–0.86] | 0.68 [0.47–0.88] | |||
Type of diabetes | GDM | 2 | 9 | 0.77 [0.66–0.89] | 0.39 | 0.80 [0.61–0.98] | 0.73 |
T2DM | 3 | 6 | 0.74 [0.60–0.89] | 0.71 [0.43–0.99] | |||
Reference Gene | beta Actin | 1 | 8 | 0.76 [0.62–0.89] | 0.81 | 0.66 [0.53–0.80] | 0.62 |
GAPDH | 1 | 2 | 0.74 [0.49–1.00] | 0.53 [0.25–0.82] |