Fig. 5

Construction of Co-expression modules used WGCNA. A Sample clustering to detect outliers. The red line represents the threshold for outlier. B Soft-threshold power analysis. The left picture shows the scale free fit index for each soft-thresholding power. The right picture displays the mean connectivity for each soft-thresholding power. C Co-expression cluster dendrogram, based on TOM similarity. Each color represents one module. D Module eigengene clustering and eigengene adjacency heatmap, which shows the correlation between each module. TOM; topological overlap matrix; WGCNA, weighted gene co-expression network analysis