Table 2 Ferroptosis-related differentially expressed genes in ACLF
Gene symbol | P Value | logFC | Gene title |
|---|---|---|---|
Upregulated genes | Â | Â | Â |
NR5A2 | 1.07E−07 | 1.28702859 | NUCLEAR receptor subfamily 5 group A member 2 |
PANX1 | 1.55E−07 | 1.24766675 | pannexin 1 |
ARRDC3 | 1.13E−06 | 2.31511952 | Arrestin domain containing 3 |
PSAT1 | 1.43E−06 | 2.96649694 | Phosphoserine aminotransferase 1 |
TIMM9 | 1.77E−06 | 1.00707478 | Translocase of inner mitochondrial membrane 9 |
PEX3 | 3.49E−06 | 1.32833114 | Peroxisomal biogenesis factor 3 |
CDO1 | 4.25E−06 | 1.14600079 | Cysteine dioxygenase type 1 |
ACADSB | 5.42E−06 | 2.22836882 | Acyl-CoA dehydrogenase short/branched chain |
SESN2 | 8.40E−06 | 1.16331947 | Sestrin 2 |
AR | 4.44E−05 | 1.0473481 | Androgen receptor |
SLC2A12 | 6.52E−05 | 1.45404063 | Solute carrier family 2 member 12 |
TTPA | 0.0001528 | 2.08107407 | Alpha tocopherol transfer protein |
PEX12 | 0.00018338 | 1.04713249 | Peroxisomal biogenesis factor 12 |
SLC16A1 | 0.00029344 | 1.6640174 | Solute carrier family 16 member 1 |
DUSP1 | 0.00035585 | 1.80166982 | Dual specificity phosphatase 1 |
TUBE1 | 0.00797734 | 1.00822644 | Tubulin epsilon 1 |
DDIT4 | 0.01616721 | 1.1277138 | DNA damage inducible transcript 4 |
HAMP | 0.01668347 | 1.86930843 | Hepcidin antimicrobial peptide |
DPP4 | 0.01743001 | 1.18827786 | Dipeptidyl peptidase 4 |
Downregulated genes | Â | Â | Â |
ACSL4 | 5.93E−08 | −1.9087248 | Acyl-CoA synthetase long chain family member 4 |
BCAT2 | 7.20E−07 | −1.6961856 | Branched chain amino acid transaminase 2 |
HRAS | 1.04E−06 | −1.0135424 | HRas proto-oncogene, GTPase |
NQO1 | 1.15E−06 | −3.1751323 | NAD(P)H quinone dehydrogenase 1 |
DAZAP1 | 1.54E−06 | −1.3918441 | DAZ associated protein 1 |
HSPB1 | 4.39E−06 | −1.3147566 | HEAT shock protein family B (small) member 1 |
SLC38A1 | 4.72E−06 | −1.3763065 | Solute carrier family 38 member 1 |
SQSTM1 | 1.10E−05 | −1.8764274 | Sequestosome 1 |
SETD1B | 4.16E−05 | −1.0151086 | SET domain containing 1B, histone lysine methyltransferase |
ASNS | 7.79E−05 | −1.691081 | Asparagine synthetase (glutamine-hydrolyzing) |
CAPG | 8.22E−05 | −1.7470416 | Capping actin protein, gelsolin like |
CDKN1A | 0.00035835 | −1.9259144 | Cyclin dependent kinase inhibitor 1A |
GPX2 | 0.0006198 | −3.2113914 | Glutathione peroxidase 2 |
NEDD4L | 0.00076102 | −1.0016884 | NEDD4 like E3 ubiquitin protein ligase |
TXNRD1 | 0.00243742 | −1.1141324 | thioredoxin reductase 1 |
GDF15 | 0.00416958 | −2.0776601 | GROWTH differentiation factor 15 |