Table 5 The PANTHER classification system of hub genes
ID | Gene name | Gene ID | PANTHER family/subfamily | PANTHER protein class |
|---|---|---|---|---|
ENO1 | Alpha-enolase ENO1 ortholog | HUMAN|HGNC = 3350|UniProtKB = P06733 | Alpha-enolase (PTHR11902:SF12) | Lyase |
MMP8 | Neutrophil collagenase MMP8 ortholog | HUMAN|HGNC = 7175|UniProtKB = P22894 | Neutrophil collagenase (PTHR10201:SF137) | Metalloprotease |
CD44 | CD44 antigen CD44 ortholog | HUMAN|HGNC = 1681|UniProtKB = P16070 | CD44 antigen (PTHR10225:SF6) | Transmembrane signal receptor |
HGF | Hepatocyte growth factor HGF ortholog | HUMAN|HGNC = 4893|UniProtKB = P14210 | Hepatocyte growth factor (PTHR24261:SF8) | Serine protease |
GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha GADD45A ortholog | HUMAN|HGNC = 4095|UniProtKB = P24522 | Growth arrest and DNA damage-inducible protein GADD45 alpha (PTHR10411:SF3) | – |
MAPK14 | Mitogen-activated protein kinase 14 MAPK14 ortholog | HUMAN|HGNC = 6876|UniProtKB = Q16539 | Mitogen-activated protein kinase 14 (PTHR24055:SF110) | Non-receptor serine/threonine protein kinase |
CD163 | Scavenger receptor cysteine-rich type 1 protein M130 CD163 ortholog | HUMAN|HGNC = 1631|UniProtKB = Q86VB7 | Scavenger receptor cysteine-rich type 1 protein M130 (PTHR19331:SF441) | Serine protease |
LCN2 | Neutrophil gelatinase-associated lipocalin LCN2 ortholog | HUMAN|HGNC = 6526|UniProtKB = P80188 | Neutrophil gelatinase-associated lipocalin (PTHR11430:SF13) | Transfer/carrier protein |
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase GAPDH ortholog | HUMAN|HGNC = 4141|UniProtKB = P04406 | Glyceraldehyde-3-phosphate dehydrogenase (PTHR10836:SF111) | Dehydrogenase |
ARG1 | Arginase-1 ARG1 ortholog | HUMAN|HGNC = 663|UniProtKB = P05089 | Arginase-1 (PTHR43782:SF2) | Hydrolase |
HERC5 | E3 ISG15–protein ligase HERC5HERC5 | HUMAN|HGNC = 24368|UniProtKB = Q9UII4 | E3 ISG15–protein ligase HERC5 (PTHR45622:SF7) | Ubiquitin-protein ligase |
IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 IFIT2 | HUMAN|HGNC = 5409|UniProtKB = P09913 | Interferon-induced protein with tetratricopeptide repeats 2 (PTHR10271:SF4) | Defense/immunity protein |
IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 IFIT3 | HUMAN|HGNC = 5411|UniProtKB = O14879 | Interferon-induced protein with tetratricopeptide repeats 3 (PTHR10271:SF3) | Defense/immunity protein |
RSAD2 | Radical S-adenosyl methionine domain-containing protein 2 RSAD2 | HUMAN|HGNC = 30908|UniProtKB = Q8WXG1 | Radical S-adenosyl methionine domain-containing protein 2 (PTHR21339:SF0) | – |
IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 IFIT1 | HUMAN|HGNC = 5407|UniProtKB = P09914 | Interferon-induced protein with tetratricopeptide repeats 1 (PTHR10271:SF16) | Defense/immunity protein |