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Table 6 Details of GO terms and KEGG pathway enrichment in co-upregulated hub genes

From: Identification of potential biomarkers and therapeutic targets for posttraumatic acute respiratory distress syndrome

Ontology

ID

Description

GeneRatio

BgRatio

pvalue

p.adjust

qvalue

BP

GO:0038066

p38MAPK cascade

3/10

53/18670

2.56e−06

5.28e−04

2.04e−04

BP

GO:0043312

Neutrophil degranulation

5/10

485/18670

2.62e−06

5.28e−04

2.04e−04

BP

GO:0002283

Neutrophil activation involved in immune response

5/10

488/18670

2.70e−06

5.28e−04

2.04e−04

BP

GO:0042119

Neutrophil activation

5/10

498/18670

2.99e−06

5.28e−04

2.04e−04

BP

GO:0002446

Neutrophil mediated immunity

5/10

499/18670

3.02e−06

5.28e−04

2.04e−04

CC

GO:0034774

Secretory granule lumen

5/10

321/19717

2.61e−07

6.17e−06

4.57e−06

CC

GO:0060205

Cytoplasmic vesicle lumen

5/10

338/19717

3.38e−07

6.17e−06

4.57e−06

CC

GO:0031983

Vesicle lumen

5/10

339/19717

3.43e−07

6.17e−06

4.57e−06

CC

GO:0035580

Specific granule lumen

3/10

62/19717

3.50e−06

4.72e−05

3.50e−05

CC

GO:0042581

Specific granule

3/10

160/19717

6.04e−05

6.52e−04

4.83e−04

MF

GO:0004252

Serine-type endopeptidase activity

2/10

160/17697

0.003

0.077

0.042

MF

GO:0008236

Serine-type peptidase activity

2/10

182/17697

0.004

0.077

0.042

MF

GO:0017171

Serine hydrolase activity

2/10

186/17697

0.005

0.077

0.042

MF

GO:0016813

Hydrolase activity, acting on carbon–nitrogen (but not peptide) bonds, in linear amidines

1/10

11/17697

0.006

0.077

0.042

MF

GO:0004707

MAP kinase activity

1/10

14/17697

0.008

0.077

0.042

KEGG

hsa01230

Biosynthesis of amino acids

3/8

75/8076

4.17e−05

0.004

0.003

KEGG

hsa05169

Epstein–Barr virus infection

3/8

202/8076

7.87e−04

0.025

0.020

KEGG

hsa05205

Proteoglycans in cancer

3/8

205/8076

8.21e−04

0.025

0.020

KEGG

hsa00010

Glycolysis/gluconeogenesis

2/8

67/8076

0.002

0.030

0.024

KEGG

hsa05218

Melanoma

2/8

72/8076

0.002

0.030

0.024