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Table 3 The frequency of alleles and genotypes of CASP8 polymorphisms in breast cancer and healthy groups

From: Genetic contribution of caspase-8 variants and haplotypes to breast cancer risk and prognosis: a case-control study in Iran

SNP ID

Genotype

Breast cancer

Control

P-value Adj. a

OR (95%CI) Adj.

rs3834129

DD

58 (12.9%)

95 (17.2%)

Reference

 

ID

185 (41.1%)

261 (47.2%)

0.158

1.49 (0.86–2.59)

II

207 (46.0%)

197 (35.6%)

0.008

2.14 (1.22–3.75)

D

301 (33.4%)

451 (40.8%)

Reference

 

I

599 (66.6%)

655 (59.2%)

0.011

1.43 (1.15–1.78)

rs2037815

AA

80 (17.8%)

130 (23.5%)

Reference

 

GA

261 (58.0%)

301 (54.4%)

0.514

1.15 (0.75–1.75)

GG

109 (24.2%)

122 (22.1%)

0.502

0.84 (0.51–1.39)

A

421 (46.8%)

561 (50.7%)

Reference

 

G

479 (53.2%)

545 (49.3%)

0.684

1.04 (0.85–1.29)

rs7608692

GG

161 (35.8%)

249 (45.0%)

Reference

 

GA

211 (46.9%)

215 (38.9%)

0.006

1.52 (1.12–2.04)

AA

78 (17.3%)

89 (16.1%)

0.136

1.35 (0.91-2.00)

G

533 (59.2%)

713 (64.5%)

Reference

 

A

367 (40.8%)

393 (35.5%)

0.179

1.16 (0.93–1.44)

rs12990906

CC

69 (15.3%)

111 (20.1%)

Reference

 

TC

196 (43.6%)

248 (44.8%)

0.172

1.41 (0.86–2.30)

TT

185 (41.1%)

194 (35.1%)

0.712

1.09 (0.69–1.73)

C

334 (37.1%)

470 (42.5%)

Reference

 

T

566 (62.9%)

636 (57.5%)

0.026

1.27 (1.03–1.58)

rs3769821

TT

273 (60.7%)

361 (65.3%)

Reference

 

TC

147 (32.7%)

143 (25.9%)

0.389

1.18 (0.81–1.72)

CC

30 (6.7%)

49 (8.9%)

0.92

1.03 (0.54–1.96)

T

693 (77.0%)

865 (78.2%)

Reference

 

C

207 (23.0%)

241 (21.8%)

0.533

1.08 (0.84-1-39)

rs6435074

CC

227 (50.4%)

294 (53.2%)

Reference

 

CA

181 (40.2%)

218 (39.4%)

0.841

1.06 (0.57–1.98)

AA

42 (9.3%)

41 (7.4%)

0.924

1.03 (0.55–1.93)

C

635 (70.6%)

806 (72.9%)

Reference

 

A

265 (29.4%)

300 (27.1%)

0.856

1.02 (0.81–1.29)

rs3754934

CC

385 (85.6%)

464 (84.1%)

Reference

 

CA

51 (11.3%)

75 (13.6%)

0.002

0.41 (0.23–0.73)

AA

14 (3.1%)

13 (2.4%)

0.856

0.89 (0.26–3.07)

C

821 (91.2%)

1005 (91.9%)

Reference

 

A

79 (8.8%)

101 (8.1%)

0.051

1.50 (0.99–2.27)

rs3817578

TT

8 (1.8%)

16 (2.9%)

Reference

 

CT

119 (26.4%)

142 (25.7%)

0.555

0.89 (0.60–1.32)

CC

323 (71.8%)

395 (71.4%)

0.88

0.91 (0.29–2.91)

T

135 (15.0%)

174 (15.7%)

Reference

 

C

765 (85.0%)

932 (84.3%)

0.993

1.00 (0.74–1.35)

rs10931936

CC

245 (54.4%)

396 (71.6%)

Reference

 

CT

168 (37.3%)

122 (21.1%)

< 0.001

2.31 (1.57–3.39)

TT

37 (8.2%)

35 (6.3%)

0.372

1.34 (0.70–2.65)

C

658 (73.1%)

914 (82.6%)

Reference

 

T

242 (26.9%)

192 (17.4%)

< 0.001

1.73 (1.34–2.23)

rs1045485

CC

30 (6.7%)

56 (10.1%)

Reference

 

GC

127 (28.2%)

142 (25.7%)

0.744

1.07 (0.72–1.58)

GG

293 (65.1%)

355 (64.2%)

0.28

0.69 (0.35–1.35)

C

187 (20.8%)

254 (23.0%)

Reference

 

G

713 (79.2%)

852 (77.0%)

0.296

1.15 (0.88–1.45)

rs1045487

GG

321 (71.3%)

403 (72.9%)

Reference

 

GA

111 (24.7%)

135 (24.4%)

0.912

1.02 (0.68–1.53)

AA

18 (4.0%)

15 (2.7%)

0.113

2.30 (0.82–6.44)

G

753 (83.7%)

941 (85.1%)

Reference

 

A

147 (16.3%)

165 (14.9%)

0.15

1.24 (0.92–1.67)

rs13113

TT

170 (37.8%)

228 (41.2%)

Reference

 

TA

204 (45.3%)

250 (45.2%)

0.804

1.04 (0.72–1.52)

AA

76 (16.9%)

75 (13.6%)

0.285

1.33 (0.79–2.24)

T

544 (60.4%)

706 (63.8%)

Reference

 

A

356 (39.6%)

400 (36.2%)

0.133

1.18 (0.95–1.46)

  1. a significant data has been shown in bold