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Table 3 Uni- and multivariate analysis for identification of prognostic factors

From: Golgi-apparatus genes related signature for predicting the progression-free interval of patients with papillary thyroid carcinoma

Characteristics

Total(N)

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Riskscore

488

4.531 (2.689–7.637)

< 0.001

3.038 (1.648–5.598)

< 0.001

Ethnicity

388

    

Not Hispanic or Latino

354

Reference

   

Hispanic or Latino

34

0.463 (0.112–1.918)

0.289

  

BRAF status

488

    

Wild type

211

Reference

   

Mutated

277

1.455 (0.801–2.645)

0.218

  

RAS status

488

    

Wild type

429

Reference

   

Mutated

59

1.640 (0.768–3.504)

0.201

  

Extrathyroid extension

471

    

Moderate/Advanced (T4)

18

Reference

   

None/Minimal

453

0.476 (0.171–1.326)

0.156

1.609 (0.457–5.668)

0.459

Neoplasm size

474

    

< 2cm

153

Reference

   

≥ 2cm

321

3.914 (1.547–9.901)

0.004

2.729 (1.040–7.159)

0.041

Histological type

488

    

Classical/Follicular

452

Reference

   

Tall Cell

36

2.417 (1.084–5.389)

0.031

1.305 (0.508–3.348)

0.580

Anatomic site

482

    

Unilateral

379

Reference

   

Bilateral

81

1.101 (0.513–2.365)

0.805

  

Isthmus

22

0.413 (0.057–3.004)

0.382

  

M stage

487

    

M0

479

Reference

   

M1

8

5.630 (2.021–15.687)

< 0.001

1.422 (0.380–5.323)

0.601

Residual tumor

426

    

R0/R1

422

Reference

   

R2

4

2.027 (0.277–14.813)

0.486

  

Ajcc_stage

486

    

Stage III/IV

162

Reference

   

Stage I/II

324

0.363 (0.207–0.638)

< 0.001

0.717 (0.279–1.845)

0.491

N stage

438

    

N0

225

Reference

   

N1

213

1.736 (0.950–3.172)

0.073

1.114 (0.559–2.218)

0.759

T stage

486

    

T1/T2

302

Reference

   

T3/T4

184

2.806 (1.569–5.018)

< 0.001

1.151 (0.539–2.458)

0.716

Gender

488

    

FEMALE

358

Reference

   

MALE

130

1.747 (0.977–3.124)

0.060

1.322 (0.697–2.509)

0.393

Age

488

    

≥ 55

163

Reference

   

< 55

325

0.443 (0.252–0.776)

0.004

0.675 (0.291–1.567)

0.360

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BMC Medical Genomics

ISSN: 1755-8794

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