Fig. 1

HERV expression in primary CD4 + T cells. (A) Raw HERV transcript counts are plotted for each HERV element. A HERV element is considered to be expressed with at least one read being mapped to the HERV loci. Black line indicates % of expressed HERVs per dataset. Datasets are identified by SRA database numbers and ordered by increasing sequencing depth. (B) Qualitative comparison of expressed HERV elements between datasets with least and highest sequencing depth. Absolute number of expressed HERV elements are presented in the Venn diagram. Bar chart below depicts distribution of mapped reads per HERV element for each Venn section. (C) Ranked HERV expression comparison between datasets from B. The Spearman correlation coefficient and p-value is indicated. (D) Pairwise comparison matrix presenting the overlap of expressed HERV elements between datasets. Order of datasets equivalent to panel A