Term | Overlap | P value | cKGs |
---|---|---|---|
Biological process | |||
Cell junction maintenance (GO:0034331) [88] | 2/14 | 6.14E−04 | CLDN1 |
Cell–cell adhesion via plasma-membrane adhesion molecules (GO:0098742) [89] | 4/170 | 0.001067 | CLDN1 |
Calcium-independent cell–cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) [89] | 2/20 | 0.00127 | CLDN1 |
Cell–cell junction organization (GO:0045216) [89] | 3/82 | 0.001342 | CLDN1 |
Negative regulation of cell population proliferation (GO:0008285) [90] | 5/379 | 0.003239 | CXCL8 |
Regulation of cell migration (GO:0030334) [91] | 5/408 | 0.00443 | MMP7;CLDN1 |
Molecular function | |||
Hormone activity (GO:0005179) [92] | 5/78 | 1.96E−06 | GUCA2A |
Guanylate cyclase activator activity (GO:0030250) [93] | 2/5 | 6.85E−05 | GUCA2B;GUCA2A |
Receptor ligand activity (GO:0048018) [94] | 6/307 | 1.56E−04 | GUCA2A |
Chloride channel activity (GO:0005254) [95] | 2/64 | 0.012507 | CLCA4 |
Metallopeptidase activity (GO:0008237) [96] | 2/121 | 0.040942 | MMP7 |
CXCR chemokine receptor binding (GO:0045236) [97] | 1/17 | 0.044125 | CXCL8 |
Cellular component | |||
Anchored component of plasma membrane (GO:0046658) [98] | 2/46 | 0.006619 | CA4 |
Collagen-containing extracellular matrix (GO:0062023) [99] | 4/380 | 0.018081 | ZG16 |
Bicellular tight junction (GO:0005923) [100] | 2/78 | 0.018197 | CLDN1 |
Apical junction complex (GO:0043296) [101] | 2/98 | 0.027852 | CLDN1 |
Cell–cell junction (GO:0005911) [102] | 3/271 | 0.035073 | CLDN1 |
KEGG | |||
Nitrogen metabolism [22] | 1/7 | 9.13E−04 | CA4 |
Proximal tubule bicarbonate reclamation [103] | 1/23 | 0.001682 | CA4 |
Cell adhesion molecules [104] | 3/148 | 0.007098 | CLDN1 |
Pathogenic Escherichia coli infection [105] | 3/197 | 0.015369 | CXCL8;CLDN1 |
Amoebiasis [44] | 2/102 | 0.029984 | CXCL8 |
Leukocyte transendothelial migration [106] | 2/114 | 0.036749 | CLDN1 |
Cytokine-cytokine receptor interaction [107] | 3/295 | 0.043339 | CXCL8 |