Sleep traits and risk of end-stage renal disease: a mendelian randomization study

Li, Kaixin; Zhao, Jiaxi; Yang, Wenjing; Ye, Zhibin

doi:10.1186/s12920-023-01497-9

BMC Medical Genomics

Table 2 Sensitivity analysis of the causal association between sleep traits and the risk of ESRD.

From: Sleep traits and risk of end-stage renal disease: a mendelian randomization study

Exposure	Outcome	MR-IVW			MR-Egger			MR-Egger intercept			MR-PRESSO
Exposure	Outcome	Q	Q_df	Q_pval	Q	Q_df	Q_pval	Intercept	SE	P val	Global test Pval
Sleeplessness/insomnia	ESRD	21.32	25	0.67	20.6	24	0.662	-0.06	0.07	0.4	0.782
Sleep duration		45.45	40	0.256	45.09	39	0.232	0.021	0.037	0.58	0.334
Morning chronotype		84.24	77	0.268	82.17	76	0.294	-0.024	0.017	0.17	0.201
Getting up in the morning		20.28	35	0.978	19.49	34	0.978	-0.025	0.028	0.38	0.976
Non-snoring		13.7	20	0.85	12.27	19	0.874	0.089	0.07	0.245	0.813
Daytime dozing		12.62	17	0.761	12.28	16	0.724	-0.053	0.09	0.567	0.783
Nap during the day		24.68	46	0.996	23.02	45	0.997	-0.046	0.036	0.204	0.997
ESRD	Sleeplessness/insomnia	18.72	19	0.475	18.56	18	0.419	-0.000575	0.00145	0.696	0.505
	Sleep duration	13.977	19	0.785	13.689	18	0.749	-0.0008	0.0015	0.598	0.805
	Morning chronotype	19.29	19	0.438	19.294	18	0.429	-0.0018	0.00198	0.367	0.378
	Getting up in the morning	12.44	19	0.866	10.28	18	0.922	0.0023	0.0015	0.159	0.834
	Non-snoring	32.58	19	0.027	29.83	18	0.039	0.0016	0.0012	0.214	0.616
	Daytime dozing	16.24	19	0.641	16.15	18	0.582	-0.00028	0.00098	0.777	0.624
	Nap during the day	24.69	19	0.17	18.97	18	0.335	-0.0026	0.0012	0.054	0.178
Sleeplessness/insomnia	Dialysis	36.41	26	0.084	28.78	25	0.273	-0.094	0.036	0.016	0.822
Sleep duration		37.87	40	0.567	36.44	39	0.587	0.047	0.039	0.239	0.604
Morning chronotype		97.76	79	0.075	97.26	78	0.069	0.013	0.019	0.528	0.094
Getting up in the morning		46.09	36	0.120	45.93	35	0.102	0.016	0.045	0.729	0.128
Non-snoring		37.39	21	0.015	36.27	20	0.014	-0.068	0.086	0.441	0.605
Daytime dozing		9.74	18	0.939	8.63	17	0.951	0.075	0.071	0.306	0.935
Nap during the day		56.12	47	0.169	56.08	46	0.147	-0.0075	0.038	0.846	0.148
Sleeplessness/insomnia	Glomerular filtration rate	15.37	10	0.119	15.12	9	0.088	0.0025	0.0065	0.706	0.103
Sleep duration		25.01	15	0.049	24.63	14	0.038	-0.0019	0.004	0.650	0.063
Morning chronotype		32.57	27	0.211	31.59	26	0.207	-0.0019	0.002	0.378	0.197
Getting up in the morning		30.22	15	0.011	30.169	14	0.007	-0.0006	0.0039	0.882	0.554
Non-snoring		18.68	10	0.044	17.67	9	0.039	0.0056	0.0079	0.492	0.054
Daytime dozing		19.15	9	0.023	18.94	8	0.015	0.0019	0.0063	0.775	0.317
Nap during the day		31.90	29	0.324	31.88	28	0.279	-0.00027	0.0019	0.888	0.368

ESRD, end-stage renal disease; OR, odds ratio; CI, confidence interval; IVW, inverse-variance weighted; FDR, P-value corrected for False Discovery Rate

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