AVPR2 is a potential prognostic biomarker and correlated with immune infiltration in head and neck squamous cell carcinoma

Mao, Linwei; Pan, Zhiyong; Chen, Wenzhi; Hu, Weiqun; Chen, Xiufen; Dai, Huiting

doi:10.1186/s12920-023-01500-3

Table 4 Correlation between AVPR2 and immune-related genes analyzed by TIMER

From: AVPR2 is a potential prognostic biomarker and correlated with immune infiltration in head and neck squamous cell carcinoma

Gene Symbols	Function	Immune Checkpoint	None		Purity
Gene Symbols	Function	Immune Checkpoint	Cor	P value	Cor	P value
HLA-DPB1	Antigen presentation	N/A	0.406	***	0.361	***
HLA-DPA1	Antigen presentation	N/A	0.362	***	0.314	***
HLA-DQA1	Antigen presentation	N/A	0.350	***	0.312	***
HLA-DRA	Antigen presentation	N/A	0.347	***	0.297	***
HLA-DQB2	Antigen presentation	N/A	0.319	***	0.285	***
HLA-DRB1	Antigen presentation	N/A	0.327	***	0.281	***
HLA-DRB5	Antigen presentation	N/A	0.314	***	0.276	***
HLA-DQB1	Antigen presentation	N/A	0.308	***	0.275	***
HLA-DQA2	Antigen presentation	N/A	0.317	***	0.270	***
MICB	Antigen presentation	N/A	0.099	0.024	0.091	0.043
HLA-B	Antigen presentation	N/A	0.085	0.052	0.045	0.321
HLA-A	Antigen presentation	N/A	0.068	0.120	0.043	0.344
MICA	Antigen presentation	N/A	0.016	0.710	0.040	0.375
HLA-C	Antigen presentation	N/A	0.074	0.092	0.032	0.479
SELP	Cell adhesion	Stimulatory	0.715	***	0.700	***
ITGB2	Cell adhesion	Stimulatory	0.427	***	0.382	***
ICAM1	Cell adhesion	Stimulatory	0.199	***	0.164	**
VTCN1	Co-inhibitor	Inhibitory	0.264	***	0.296	***
SLAMF7	Co-inhibitor	Inhibitory	0.301	***	0.245	***
BTN3A1	Co-inhibitor	Stimulatory	0.263	***	0.230	***
BTN3A2	Co-inhibitor	Stimulatory	0.262	***	0.224	***
C10orf54	Co-inhibitor	Inhibitory	0.247	***	0.202	***
CD276	Co-inhibitor	Inhibitory	− 0.040	0.365	− 0.042	0.357
PDCD1LG2	Co-inhibitor	N/A	0.086	0.050	0.029	0.517
CD274	Co-inhibitor	Inhibitory	0.043	0.322	− 0.004	0.922
CD28	Co-stimulator	Stimulatory	0.455	***	0.420	***
ICOSLG	Co-stimulator	Stimulatory	0.324	***	0.318	***
CD80	Co-stimulator	Stimulatory	0.156	**	0.111	0.014
CD40LG	Ligand	Stimulatory	0.493	***	0.461	***
IL1A	Ligand	Stimulatory	− 0.319	***	− 0.353	***
TNFSF4	Ligand	Stimulatory	0.326	***	0.315	***
CX3CL1	Ligand	Stimulatory	0.309	***	0.309	***
IL10	Ligand	Inhibitory	0.326	***	0.284	***
IL12A	Ligand	Stimulatory	0.240	***	0.246	***
IL2	Ligand	Stimulatory	0.280	***	0.242	***
IL13	Ligand	Inhibitory	0.237	***	0.210	***
IFNA1	Ligand	Stimulatory	− 0.155	***	− 0.171	**
VEGFB	Ligand	Inhibitory	0.138	*	0.168	**
IL1B	Ligand	Stimulatory	− 0.135	*	− 0.157	**
cxcL9	Ligand	Stimulatory	0.198	***	0.147	*
VEGFA	Ligand	Inhibitory	− 0.187	***	− 0.146	*
CCL5	Ligand	Stimulatory	0.191	***	0.143	*
IFNG	Ligand	Stimulatory	0.182	***	0.135	*
TNF	Ligand	Stimulatory	0.144	*	0.128	*
IL4	Ligand	Inhibitory	0.125	*	0.126	*
TGFB1	Ligand	Inhibitory	− 0.103	0.018	− 0.119	*
CD70	Ligand	Stimulatory	0.082	0.060	0.061	0.175
TNFSF9	Ligand	Stimulatory	− 0.048	0.277	− 0.052	0.253
CXCL10	Ligand	Stimulatory	0.063	0.149	0.018	0.696
IFNA2	Ligand	Stimulatory	0.001	0.990	0.014	0.758
ENTPD1	Other	Stimulatory	0.515	***	0.495	***
PRF1	Other	Stimulatory	0.266	***	0.221	***
GZMA	Other	Stimulatory	0.241	***	0.193	***
IDO1	Other	Inhibitory	0.182	***	0.155	**
HMGB1	Other	Stimulatory	0.043	0.331	0.062	0.167
ARG1	Other	Inhibitory	0.004	0.927	− 0.018	0.687
ADORA2A	Receptor	Inhibitory	0.549	***	0.524	***
EDNRB	Receptor	Inhibitory	0.505	***	0.501	***
BTLA	Receptor	Inhibitory	0.512	***	0.490	***
CD27	Receptor	Stimulatory	0.505	***	0.481	***
TNFRSF4	Receptor	Stimulatory	0.444	***	0.437	***
TLR4	Receptor	Stimulatory	0.450	***	0.410	***
TNFRSF14	Receptor	Stimulatory	0.418	***	0.391	***
CD4	Receptor	Stimulatory	0.417	***	0.374	***
TIGIT	Receptor	Inhibitory	0.380	***	0.342	***
PDCD1	Receptor	Inhibitory	0.350	***	0.310	***
CTLA4	Receptor	Inhibitory	0.329	***	0.295	***
TNFRSF18	Receptor	Stimulatory	0.256	***	0.292	***
IL2RA	Receptor	Stimulatory	0.326	***	0.288	***
Icos	Receptor	Stimulatory	0.307	***	0.264	***
TNFRSF9	Receptor	Stimulatory	0.299	***	0.263	***
HAVCR2	Receptor	Inhibitory	0.286	***	0.239	***
LAG3	Receptor	Inhibitory	0.232	***	0.200	***
KIR2DL3	Receptor	Inhibitory	0.176	***	0.144	*
KIR2DL1	Receptor	Inhibitory	0.143	*	0.124	*

Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity
*P < 0.01; **P < 0.001; ***P < 0.0001

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ISSN: 1755-8794

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