Table 1 AYPG course schedule containing learning objectives: the course was structured into 12 sessions of three hours

1

22

Introduction

General overview

German Genetic Diagnostics Act (Gendiagnostikgesetz)

Understand context and decisions facing patients, researchers, and clinicians

2

25

The Human Genome

Basics concepts of molecular genetics/the human genome

Genetic diversity and genetic variation

Population structure

3

26

Pharmacogenomics

Basic concepts and examples of pharmacogenomics

CPIC guideline interpretation

4

27

Genomic medicine

Effects of genetic variations, clinical relevance

5–6

32

Genotype–phenotype relationship

GWAS and GWAS meta-analyses: Basic concepts, examples

Hands on exercise using PLINK

Explore GWAS summary results using FUMA and MAGMA

7

32

Technical Aspects

Genotyping & genome sequencing techniques

8

32

Genomic Research, Annotation

Overview genomic databases/tools and data resources used in annotating and interpreting a personal genome

Hands on exercise: Exploration and interpretation of selected association results

9

32

Direct to consumer testing

Basic concepts, Polygenic risk scores

Understand ethical, legal and social implications of genetic testing

9

32

Disease Risk

Interpretation of SNV findings (effect size, causal vs. not, multi-allelic models) and the limitations thereof

9–10

32

Polygenic traits and diseases

Basic concepts, Polygenic risk scores

Calculate polygenic risk score using the openSNP dataset

10

32

Ancestry

Population structure in genomes and basic concepts (MDS) 

Infer genetic ancestry of a genome from the openSNP dataset

11

32

Genomic Research, Annotation

Exploration of selected personal genomic data

Analyze found SNVs associated with disease risk in the context of public databases, literature, and other resources

Discussion and Presentation

12

32

Q&A with Human Geneticists

Discussion

Review current understanding of how patients respond to genetic testing results emotionally and behaviorally