Fig. 3From: WFS1 autosomal dominant variants linked with hearing loss: update on structural analysis and cochlear implant outcome3D modeling and structural analysis of WFS1 p.Phe515LeufsTer28. WFS1 3D model generated from Colabfold. (A) WFS1 Wild type (B) WFS1 p.Phe515LeufsTer28. Cytoplasmic domain (cyan), TM domain (green), ER-luminal domain (blue). More than one-third of the length of the protein is truncated, including TM domain 7–9 and the ER-luminal domain. Conformational changes of WFS1 mutant (p.Phe515LeufsTer28) were observedBack to article page