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Fig. 3 | BMC Medical Genomics

Fig. 3

From: WFS1 autosomal dominant variants linked with hearing loss: update on structural analysis and cochlear implant outcome

Fig. 3

3D modeling and structural analysis of WFS1 p.Phe515LeufsTer28. WFS1 3D model generated from Colabfold. (A) WFS1 Wild type (B) WFS1 p.Phe515LeufsTer28. Cytoplasmic domain (cyan), TM domain (green), ER-luminal domain (blue). More than one-third of the length of the protein is truncated, including TM domain 7–9 and the ER-luminal domain. Conformational changes of WFS1 mutant (p.Phe515LeufsTer28) were observed

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